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Page 1
Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.
Palmer JT, Axford LC, Barker S, Bennett JM, Blair M, Collins I, Davies DT, Ford L, Gannon CT, Lancett P, Logan A, Lunniss CJ, Morton CJ, Offermann DA, Pitt GR, Rao BN, Singh AK, Shukla T, Srivastava A, Stokes NR, Thomaides-Brears HB, Yadav A, Haydon DJ. Palmer JT, et al. Among authors: stokes nr. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4215-22. doi: 10.1016/j.bmcl.2014.07.037. Epub 2014 Jul 19. Bioorg Med Chem Lett. 2014. PMID: 25086682
Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.
Czaplewski LG, Collins I, Boyd EA, Brown D, East SP, Gardiner M, Fletcher R, Haydon DJ, Henstock V, Ingram P, Jones C, Noula C, Kennison L, Rockley C, Rose V, Thomaides-Brears HB, Ure R, Whittaker M, Stokes NR. Czaplewski LG, et al. Among authors: stokes nr. Bioorg Med Chem Lett. 2009 Jan 15;19(2):524-7. doi: 10.1016/j.bmcl.2008.11.021. Epub 2008 Nov 13. Bioorg Med Chem Lett. 2009. PMID: 19064318
Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties.
Haydon DJ, Bennett JM, Brown D, Collins I, Galbraith G, Lancett P, Macdonald R, Stokes NR, Chauhan PK, Sutariya JK, Nayal N, Srivastava A, Beanland J, Hall R, Henstock V, Noula C, Rockley C, Czaplewski L. Haydon DJ, et al. Among authors: stokes nr. J Med Chem. 2010 May 27;53(10):3927-36. doi: 10.1021/jm9016366. J Med Chem. 2010. PMID: 20426423 Free PMC article.
Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.
Stokes NR, Thomaides-Brears HB, Barker S, Bennett JM, Berry J, Collins I, Czaplewski LG, Gamble V, Lancett P, Logan A, Lunniss CJ, Peasley H, Pommier S, Price D, Smee C, Haydon DJ. Stokes NR, et al. Antimicrob Agents Chemother. 2013 Dec;57(12):5977-86. doi: 10.1128/AAC.00719-13. Epub 2013 Sep 16. Antimicrob Agents Chemother. 2013. PMID: 24041906 Free PMC article.
Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.
Axford LC, Agarwal PK, Anderson KH, Andrau LN, Atherall J, Barker S, Bennett JM, Blair M, Collins I, Czaplewski LG, Davies DT, Gannon CT, Kumar D, Lancett P, Logan A, Lunniss CJ, Mitchell DR, Offermann DA, Palmer JT, Palmer N, Pitt GR, Pommier S, Price D, Narasinga Rao B, Saxena R, Shukla T, Singh AK, Singh M, Srivastava A, Steele C, Stokes NR, Thomaides-Brears HB, Tyndall EM, Watson D, Haydon DJ. Axford LC, et al. Among authors: stokes nr. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6598-603. doi: 10.1016/j.bmcl.2013.10.058. Epub 2013 Nov 4. Bioorg Med Chem Lett. 2013. PMID: 24239017
Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ.
Stokes NR, Baker N, Bennett JM, Chauhan PK, Collins I, Davies DT, Gavade M, Kumar D, Lancett P, Macdonald R, Macleod L, Mahajan A, Mitchell JP, Nayal N, Nayal YN, Pitt GR, Singh M, Yadav A, Srivastava A, Czaplewski LG, Haydon DJ. Stokes NR, et al. Bioorg Med Chem Lett. 2014 Jan 1;24(1):353-9. doi: 10.1016/j.bmcl.2013.11.002. Epub 2013 Nov 13. Bioorg Med Chem Lett. 2014. PMID: 24287381
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.
Haydon DJ, Stokes NR, Ure R, Galbraith G, Bennett JM, Brown DR, Baker PJ, Barynin VV, Rice DW, Sedelnikova SE, Heal JR, Sheridan JM, Aiwale ST, Chauhan PK, Srivastava A, Taneja A, Collins I, Errington J, Czaplewski LG. Haydon DJ, et al. Among authors: stokes nr. Science. 2008 Sep 19;321(5896):1673-5. doi: 10.1126/science.1159961. Science. 2008. PMID: 18801997
An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.
Stokes NR, Baker N, Bennett JM, Berry J, Collins I, Czaplewski LG, Logan A, Macdonald R, Macleod L, Peasley H, Mitchell JP, Nayal N, Yadav A, Srivastava A, Haydon DJ. Stokes NR, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):317-25. doi: 10.1128/AAC.01580-12. Epub 2012 Oct 31. Antimicrob Agents Chemother. 2013. PMID: 23114779 Free PMC article.
Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.
Cooper IR, McCarroll AJ, McGarry D, Kirkham J, Pichowicz M, Walker R, Warrilow C, Salisbury AM, Savage VJ, Moyo E, Forward H, Cheung J, Metzger R, Gault Z, Nelson G, Hughes D, Cao S, Maclean J, Charrier C, Craighead M, Best S, Stokes NR, Ratcliffe AJ. Cooper IR, et al. Among authors: stokes nr. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4179-83. doi: 10.1016/j.bmcl.2016.07.061. Epub 2016 Jul 28. Bioorg Med Chem Lett. 2016. PMID: 27499455 Free article.
23 results