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7,036 results

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Page 1
Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.
Palmer JT, Axford LC, Barker S, Bennett JM, Blair M, Collins I, Davies DT, Ford L, Gannon CT, Lancett P, Logan A, Lunniss CJ, Morton CJ, Offermann DA, Pitt GR, Rao BN, Singh AK, Shukla T, Srivastava A, Stokes NR, Thomaides-Brears HB, Yadav A, Haydon DJ. Palmer JT, et al. Among authors: srivastava a. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4215-22. doi: 10.1016/j.bmcl.2014.07.037. Epub 2014 Jul 19. Bioorg Med Chem Lett. 2014. PMID: 25086682
Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties.
Haydon DJ, Bennett JM, Brown D, Collins I, Galbraith G, Lancett P, Macdonald R, Stokes NR, Chauhan PK, Sutariya JK, Nayal N, Srivastava A, Beanland J, Hall R, Henstock V, Noula C, Rockley C, Czaplewski L. Haydon DJ, et al. Among authors: srivastava a. J Med Chem. 2010 May 27;53(10):3927-36. doi: 10.1021/jm9016366. J Med Chem. 2010. PMID: 20426423 Free PMC article.
Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.
Axford LC, Agarwal PK, Anderson KH, Andrau LN, Atherall J, Barker S, Bennett JM, Blair M, Collins I, Czaplewski LG, Davies DT, Gannon CT, Kumar D, Lancett P, Logan A, Lunniss CJ, Mitchell DR, Offermann DA, Palmer JT, Palmer N, Pitt GR, Pommier S, Price D, Narasinga Rao B, Saxena R, Shukla T, Singh AK, Singh M, Srivastava A, Steele C, Stokes NR, Thomaides-Brears HB, Tyndall EM, Watson D, Haydon DJ. Axford LC, et al. Among authors: srivastava a. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6598-603. doi: 10.1016/j.bmcl.2013.10.058. Epub 2013 Nov 4. Bioorg Med Chem Lett. 2013. PMID: 24239017
Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ.
Stokes NR, Baker N, Bennett JM, Chauhan PK, Collins I, Davies DT, Gavade M, Kumar D, Lancett P, Macdonald R, Macleod L, Mahajan A, Mitchell JP, Nayal N, Nayal YN, Pitt GR, Singh M, Yadav A, Srivastava A, Czaplewski LG, Haydon DJ. Stokes NR, et al. Among authors: srivastava a. Bioorg Med Chem Lett. 2014 Jan 1;24(1):353-9. doi: 10.1016/j.bmcl.2013.11.002. Epub 2013 Nov 13. Bioorg Med Chem Lett. 2014. PMID: 24287381
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.
Haydon DJ, Stokes NR, Ure R, Galbraith G, Bennett JM, Brown DR, Baker PJ, Barynin VV, Rice DW, Sedelnikova SE, Heal JR, Sheridan JM, Aiwale ST, Chauhan PK, Srivastava A, Taneja A, Collins I, Errington J, Czaplewski LG. Haydon DJ, et al. Among authors: srivastava a. Science. 2008 Sep 19;321(5896):1673-5. doi: 10.1126/science.1159961. Science. 2008. PMID: 18801997
An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.
Stokes NR, Baker N, Bennett JM, Berry J, Collins I, Czaplewski LG, Logan A, Macdonald R, Macleod L, Peasley H, Mitchell JP, Nayal N, Yadav A, Srivastava A, Haydon DJ. Stokes NR, et al. Among authors: srivastava a. Antimicrob Agents Chemother. 2013 Jan;57(1):317-25. doi: 10.1128/AAC.01580-12. Epub 2012 Oct 31. Antimicrob Agents Chemother. 2013. PMID: 23114779 Free PMC article.
Baylis-Hillman reaction: convenient ascending syntheses and biological evaluation of acyclic deoxy monosaccharides as potential antimycobacterial agents.
Pathak R, Pant CS, Shaw AK, Bhaduri AP, Gaikwad AN, Sinha S, Srivastava A, Srivastava KK, Chaturvedi V, Srivastava R, Srivastava BS. Pathak R, et al. Among authors: srivastava kk, srivastava bs, srivastava r, srivastava a. Bioorg Med Chem. 2002 Oct;10(10):3187-96. doi: 10.1016/s0968-0896(02)00210-9. Bioorg Med Chem. 2002. PMID: 12150864
Higher acyclic nitrogen containing deoxy sugar derivatives: a new lead in the generation of antimycobacterial chemotherapeutics.
Pathak R, Shaw AK, Bhaduri AP, Chandrasekhar KV, Srivastava A, Srivastava KK, Chaturvedi V, Srivastava R, Srivastava BS, Arora S, Sinha S. Pathak R, et al. Among authors: srivastava kk, srivastava bs, srivastava r, srivastava a. Bioorg Med Chem. 2002 Jun;10(6):1695-702. doi: 10.1016/s0968-0896(02)00045-7. Bioorg Med Chem. 2002. PMID: 11937328
7,036 results