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Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis.
Calabro SR, Maczurek AE, Morgan AJ, Tu T, Wen VW, Yee C, Mridha A, Lee M, d'Avigdor W, Locarnini SA, McCaughan GW, Warner FJ, McLennan SV, Shackel NA. Calabro SR, et al. Among authors: wen vw. PLoS One. 2014 Jul 30;9(7):e90571. doi: 10.1371/journal.pone.0090571. eCollection 2014. PLoS One. 2014. PMID: 25076423 Free PMC article.
A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.
Somers K, Wen VW, Middlemiss SMC, Osborne B, Forgham H, Jung M, Karsa M, Clifton M, Bongers A, Gao J, Mayoh C, Raoufi-Rad N, Kusnadi EP, Hannan KM, Scott DA, Kwek A, Liu B, Flemming C, Chudakova DA, Pandher R, Failes TW, Lim J, Angeli A, Osterman AL, Imamura T, Kees UR, Supuran CT, Pearson RB, Hannan RD, Davis TP, McCarroll J, Kavallaris M, Turner N, Gudkov AV, Haber M, Norris MD, Henderson MJ. Somers K, et al. Among authors: wen vw. Oncogene. 2019 May;38(20):3824-3842. doi: 10.1038/s41388-018-0666-5. Epub 2019 Jan 22. Oncogene. 2019. PMID: 30670779 Free PMC article.
Targeting telomerase in hematologic malignancy.
Maritz MF, Napier CE, Wen VW, MacKenzie KL. Maritz MF, et al. Among authors: wen vw. Future Oncol. 2010 May;6(5):769-89. doi: 10.2217/fon.10.42. Future Oncol. 2010. PMID: 20465390 Review.
CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.
Somers K, Chudakova DA, Middlemiss SM, Wen VW, Clifton M, Kwek A, Liu B, Mayoh C, Bongers A, Karsa M, Pan S, Cruikshank S, Scandlyn M, Hoang W, Imamura T, Kees UR, Gudkov AV, Chernova OB, Haber M, Norris MD, Henderson MJ. Somers K, et al. Among authors: wen vw. Oncotarget. 2016 Jul 19;7(29):46067-46087. doi: 10.18632/oncotarget.10022. Oncotarget. 2016. PMID: 27317766 Free PMC article.