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Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.
Shahzad K, Bock F, Dong W, Wang H, Kopf S, Kohli S, Al-Dabet MM, Ranjan S, Wolter J, Wacker C, Biemann R, Stoyanov S, Reymann K, Söderkvist P, Groß O, Schwenger V, Pahernik S, Nawroth PP, Gröne HJ, Madhusudhan T, Isermann B. Shahzad K, et al. Among authors: nawroth pp. Kidney Int. 2015 Jan;87(1):74-84. doi: 10.1038/ki.2014.271. Epub 2014 Jul 30. Kidney Int. 2015. PMID: 25075770 Free PMC article.
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.
Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. Bock F, et al. Among authors: nawroth pp. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):648-53. doi: 10.1073/pnas.1218667110. Epub 2012 Dec 24. Proc Natl Acad Sci U S A. 2013. PMID: 23267072 Free PMC article.
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
Shahzad K, Bock F, Al-Dabet MM, Gadi I, Kohli S, Nazir S, Ghosh S, Ranjan S, Wang H, Madhusudhan T, Nawroth PP, Isermann B. Shahzad K, et al. Among authors: nawroth pp. J Am Soc Nephrol. 2016 Aug;27(8):2270-5. doi: 10.1681/ASN.2015060676. Epub 2016 Feb 1. J Am Soc Nephrol. 2016. PMID: 26832955 Free PMC article.
Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy.
Marquardt A, Al-Dabet MM, Ghosh S, Kohli S, Manoharan J, ElWakiel A, Gadi I, Bock F, Nazir S, Wang H, Lindquist JA, Nawroth PP, Madhusudhan T, Mertens PR, Shahzad K, Isermann B. Marquardt A, et al. Among authors: nawroth pp. J Am Soc Nephrol. 2017 Nov;28(11):3182-3189. doi: 10.1681/ASN.2016101123. Epub 2017 Jul 10. J Am Soc Nephrol. 2017. PMID: 28696246 Free PMC article.
Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy.
Wang H, Madhusudhan T, He T, Hummel B, Schmidt S, Vinnikov IA, Shahzad K, Kashif M, Muller-Krebs S, Schwenger V, Bierhaus A, Rudofsky G, Nawroth PP, Isermann B. Wang H, et al. Among authors: nawroth pp. Blood. 2011 May 12;117(19):5231-42. doi: 10.1182/blood-2010-10-314773. Epub 2011 Mar 9. Blood. 2011. PMID: 21389321 Free article.
Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes.
Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, Isermann B. Madhusudhan T, et al. Among authors: nawroth pp. Blood. 2012 Jan 19;119(3):874-83. doi: 10.1182/blood-2011-07-365973. Epub 2011 Nov 23. Blood. 2012. PMID: 22117049 Free PMC article.
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Madhusudhan T, et al. Among authors: nawroth pp. Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7. Blood. 2017. PMID: 28687614 Free PMC article.
600 results