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Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.
Wang CQ, Krishnan V, Tay LS, Chin DW, Koh CP, Chooi JY, Nah GS, Du L, Jacob B, Yamashita N, Lai SK, Tan TZ, Mori S, Tanuichi I, Tergaonkar V, Ito Y, Osato M. Wang CQ, et al. Among authors: jacob b. Cell Rep. 2014 Aug 7;8(3):767-82. doi: 10.1016/j.celrep.2014.06.046. Epub 2014 Jul 24. Cell Rep. 2014. PMID: 25066130 Free article.
Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult.
Motoda L, Osato M, Yamashita N, Jacob B, Chen LQ, Yanagida M, Ida H, Wee HJ, Sun AX, Taniuchi I, Littman D, Ito Y. Motoda L, et al. Among authors: jacob b. Stem Cells. 2007 Dec;25(12):2976-86. doi: 10.1634/stemcells.2007-0061. Epub 2007 Sep 6. Stem Cells. 2007. PMID: 17823240
Stem cell exhaustion and leukemogenesis.
Jacob B, Osato M. Jacob B, et al. J Cell Biochem. 2009 Jun 1;107(3):393-9. doi: 10.1002/jcb.22150. J Cell Biochem. 2009. PMID: 19347871 Review.
Runx family genes, niche, and stem cell quiescence.
Wang CQ, Jacob B, Nah GS, Osato M. Wang CQ, et al. Among authors: jacob b. Blood Cells Mol Dis. 2010 Apr 15;44(4):275-86. doi: 10.1016/j.bcmd.2010.01.006. Epub 2010 Feb 9. Blood Cells Mol Dis. 2010. PMID: 20144877 Review.
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.
Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG. Bard-Chapeau EA, et al. Among authors: jacob b. PLoS One. 2014 Feb 27;9(2):e89397. doi: 10.1371/journal.pone.0089397. eCollection 2014. PLoS One. 2014. PMID: 24586749 Free PMC article.
Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML.
Powell JA, Thomas D, Barry EF, Kok CH, McClure BJ, Tsykin A, To LB, Brown A, Lewis ID, Herbert K, Goodall GJ, Speed TP, Asou N, Jacob B, Osato M, Haylock DN, Nilsson SK, D'Andrea RJ, Lopez AF, Guthridge MA. Powell JA, et al. Among authors: jacob b. Blood. 2009 Nov 26;114(23):4859-70. doi: 10.1182/blood-2009-02-204818. Epub 2009 Oct 5. Blood. 2009. PMID: 19805619 Free article.
433 results