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The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives.
Agelis G, Resvani A, Durdagi S, Spyridaki K, Tůmová T, Slaninová J, Giannopoulos P, Vlahakos D, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: liapakis g. Eur J Med Chem. 2012 Sep;55:358-74. doi: 10.1016/j.ejmech.2012.07.040. Epub 2012 Jul 31. Eur J Med Chem. 2012. PMID: 22889560
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.
Agelis G, Resvani A, Koukoulitsa C, Tůmová T, Slaninová J, Kalavrizioti D, Spyridaki K, Afantitis A, Melagraki G, Siafaka A, Gkini E, Megariotis G, Grdadolnik SG, Papadopoulos MG, Vlahakos D, Maragoudakis M, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: liapakis g. Eur J Med Chem. 2013 Apr;62:352-70. doi: 10.1016/j.ejmech.2012.12.044. Epub 2013 Jan 2. Eur J Med Chem. 2013. PMID: 23376252 Free article.
GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.
Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C. Karampelas T, et al. Among authors: liapakis g. Bioconjug Chem. 2014 Apr 16;25(4):813-23. doi: 10.1021/bc500081g. Epub 2014 Apr 3. Bioconjug Chem. 2014. PMID: 24661240
Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor: role in activation and allosteric antagonism.
Spyridaki K, Matsoukas MT, Cordomi A, Gkountelias K, Papadokostaki M, Mavromoustakos T, Logothetis DE, Margioris AN, Pardo L, Liapakis G. Spyridaki K, et al. Among authors: liapakis g. J Biol Chem. 2014 Jul 4;289(27):18966-77. doi: 10.1074/jbc.M113.544460. Epub 2014 May 16. J Biol Chem. 2014. PMID: 24838244 Free PMC article.
Selective antagonism of CRF1 receptor by a substituted pyrimidine.
Sakellaris S, Matsoukas MT, Karageorgos V, Poulaki S, Kuppast B, Margioris A, Venihaki M, Fahmy H, Liapakis G. Sakellaris S, et al. Among authors: liapakis g. Hormones (Athens). 2019 Jun;18(2):215-221. doi: 10.1007/s42000-019-00105-9. Epub 2019 Apr 12. Hormones (Athens). 2019. PMID: 30980254
69 results