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A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche.
Charbord P, Pouget C, Binder H, Dumont F, Stik G, Levy P, Allain F, Marchal C, Richter J, Uzan B, Pflumio F, Letourneur F, Wirth H, Dzierzak E, Traver D, Jaffredo T, Durand C. Charbord P, et al. Among authors: uzan b. Cell Stem Cell. 2014 Sep 4;15(3):376-391. doi: 10.1016/j.stem.2014.06.005. Epub 2014 Jul 17. Cell Stem Cell. 2014. PMID: 25042701 Free article.
Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors.
Chabi S, Uzan B, Naguibneva I, Rucci J, Fahy L, Calvo J, Arcangeli ML, Mazurier F, Pflumio F, Haddad R. Chabi S, et al. Among authors: uzan b. Cell Rep. 2019 Nov 19;29(8):2307-2320.e6. doi: 10.1016/j.celrep.2019.10.050. Cell Rep. 2019. PMID: 31747603 Free article.
Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression.
Uzan B, Poglio S, Gerby B, Wu CL, Gross J, Armstrong F, Calvo J, Cahu X, Deswarte C, Dumont F, Passaro D, Besnard-Guérin C, Leblanc T, Baruchel A, Landman-Parker J, Ballerini P, Baud V, Ghysdael J, Baleydier F, Porteu F, Pflumio F. Uzan B, et al. EMBO Mol Med. 2014 Jun;6(6):821-34. doi: 10.1002/emmm.201303286. Epub 2014 Apr 6. EMBO Mol Med. 2014. PMID: 24778454 Free PMC article.
Rapid childhood T-ALL growth in xenograft models correlates with mature phenotype and NF-κB pathway activation but not with poor prognosis.
Poglio S, Cahu X, Uzan B, Besnard-Guérin C, Lapillonne H, Leblanc T, Baruchel A, Landman-Parker J, Petit A, Baleydier F, Amsellem S, Baud V, Ballerini P, Pflumio F. Poglio S, et al. Among authors: uzan b. Leukemia. 2015 Apr;29(4):977-80. doi: 10.1038/leu.2014.317. Epub 2014 Nov 5. Leukemia. 2015. PMID: 25371179 No abstract available.
Ultra-high-dose-rate FLASH and Conventional-Dose-Rate Irradiation Differentially Affect Human Acute Lymphoblastic Leukemia and Normal Hematopoiesis.
Chabi S, To THV, Leavitt R, Poglio S, Jorge PG, Jaccard M, Petersson K, Petit B, Roméo PH, Pflumio F, Vozenin MC, Uzan B. Chabi S, et al. Among authors: uzan b. Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):819-829. doi: 10.1016/j.ijrobp.2020.10.012. Epub 2020 Oct 17. Int J Radiat Oncol Biol Phys. 2021. PMID: 33075474 Free article.
SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia.
Pasmant E, Gilbert-Dussardier B, Petit A, de Laval B, Luscan A, Gruber A, Lapillonne H, Deswarte C, Goussard P, Laurendeau I, Uzan B, Pflumio F, Brizard F, Vabres P, Naguibvena I, Fasola S, Millot F, Porteu F, Vidaud D, Landman-Parker J, Ballerini P. Pasmant E, et al. Among authors: uzan b. Oncogene. 2015 Jan 29;34(5):631-8. doi: 10.1038/onc.2013.587. Epub 2014 Jan 27. Oncogene. 2015. PMID: 24469042
T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7.
Buffière A, Uzan B, Aucagne R, Hermetet F, Mas M, Nassurdine S, Aznague A, Carmignac V, Tournier B, Bouchot O, Ballerini P, Barata JT, Bastie JN, Delva L, Pflumio F, Quéré R. Buffière A, et al. Among authors: uzan b. Oncogene. 2019 Nov;38(48):7357-7365. doi: 10.1038/s41388-019-0921-4. Epub 2019 Aug 15. Oncogene. 2019. PMID: 31417180
Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.
Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. Nguyen TL, et al. Among authors: uzan b. Mol Oncol. 2021 May;15(5):1412-1431. doi: 10.1002/1878-0261.12877. Epub 2021 Feb 13. Mol Oncol. 2021. PMID: 33314742 Free PMC article.
32 results