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A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.
Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E. Schmitz AL, et al. Among authors: hiltensperger g. Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003. Chem Biol. 2014. PMID: 25036778 Free PMC article.
A small-molecule inhibitor of Nipah virus envelope protein-mediated membrane fusion.
Niedermeier S, Singethan K, Rohrer SG, Matz M, Kossner M, Diederich S, Maisner A, Schmitz J, Hiltensperger G, Baumann K, Holzgrabe U, Schneider-Schaulies J. Niedermeier S, et al. Among authors: hiltensperger g. J Med Chem. 2009 Jul 23;52(14):4257-65. doi: 10.1021/jm900411s. J Med Chem. 2009. PMID: 19499921
Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity.
Hiltensperger G, Hecht N, Kaiser M, Rybak JC, Hoerst A, Dannenbauer N, Müller-Buschbaum K, Bruhn H, Esch H, Lehmann L, Meinel L, Holzgrabe U. Hiltensperger G, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4442-52. doi: 10.1128/AAC.01757-15. Print 2016 Aug. Antimicrob Agents Chemother. 2016. PMID: 27139467 Free PMC article.
Mechanism for active membrane fusion triggering by morbillivirus attachment protein.
Ader N, Brindley M, Avila M, Örvell C, Horvat B, Hiltensperger G, Schneider-Schaulies J, Vandevelde M, Zurbriggen A, Plemper RK, Plattet P. Ader N, et al. Among authors: hiltensperger g. J Virol. 2013 Jan;87(1):314-26. doi: 10.1128/JVI.01826-12. Epub 2012 Oct 17. J Virol. 2013. PMID: 23077316 Free PMC article.