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A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.
Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E. Schmitz AL, et al. Among authors: harden tk. Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003. Chem Biol. 2014. PMID: 25036778 Free PMC article.
The experimental power of FR900359 to study Gq-regulated biological processes.
Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E. Schrage R, et al. Among authors: harden tk. Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156. Nat Commun. 2015. PMID: 26658454 Free PMC article.
Potent and Selective Peptide-based Inhibition of the G Protein Gαq.
Charpentier TH, Waldo GL, Lowery-Gionta EG, Krajewski K, Strahl BD, Kash TL, Harden TK, Sondek J. Charpentier TH, et al. Among authors: harden tk. J Biol Chem. 2016 Dec 2;291(49):25608-25616. doi: 10.1074/jbc.M116.740407. Epub 2016 Oct 14. J Biol Chem. 2016. PMID: 27742837 Free PMC article.
Activation of human phospholipase C-eta2 by Gbetagamma.
Zhou Y, Sondek J, Harden TK. Zhou Y, et al. Among authors: harden tk. Biochemistry. 2008 Apr 15;47(15):4410-7. doi: 10.1021/bi800044n. Epub 2008 Mar 25. Biochemistry. 2008. PMID: 18361507 Free PMC article.
Membrane-induced allosteric control of phospholipase C-β isozymes.
Charpentier TH, Waldo GL, Barrett MO, Huang W, Zhang Q, Harden TK, Sondek J. Charpentier TH, et al. Among authors: harden tk. J Biol Chem. 2014 Oct 24;289(43):29545-57. doi: 10.1074/jbc.M114.586784. Epub 2014 Sep 5. J Biol Chem. 2014. PMID: 25193662 Free PMC article.
Direct activation of phospholipase C-epsilon by Rho.
Wing MR, Snyder JT, Sondek J, Harden TK. Wing MR, et al. Among authors: harden tk. J Biol Chem. 2003 Oct 17;278(42):41253-8. doi: 10.1074/jbc.M306904200. Epub 2003 Aug 4. J Biol Chem. 2003. PMID: 12900402 Free article.
300 results