Deacon S - Search Results

1

Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints.

Beeharry N, Banina E, Hittle J, Skobeleva N, Khazak V, Deacon S, Andrake M, Egleston BL, Peterson JR, Astsaturov I, Yen TJ. Beeharry N, et al. Among authors: deacon s. Cell Cycle. 2014;13(14):2172-91. doi: 10.4161/cc.29214. Epub 2014 Jun 23. Cell Cycle. 2014. PMID: 24955955 Free PMC article.

2

Chemical inhibition through conformational stabilization of Rho GTPase effectors.

Deacon SW, Peterson JR. Deacon SW, et al. Handb Exp Pharmacol. 2008;(186):431-60. doi: 10.1007/978-3-540-72843-6_18. Handb Exp Pharmacol. 2008. PMID: 18491063 Review.

3

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. Anastassiadis T, et al. Nat Biotechnol. 2011 Oct 30;29(11):1039-45. doi: 10.1038/nbt.2017. Nat Biotechnol. 2011. PMID: 22037377 Free PMC article.

4

A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.

Anastassiadis T, Duong-Ly KC, Deacon SW, Lafontant A, Ma H, Devarajan K, Dunbrack RL Jr, Wu J, Peterson JR. Anastassiadis T, et al. J Biol Chem. 2013 Sep 27;288(39):28068-77. doi: 10.1074/jbc.M113.505032. Epub 2013 Aug 9. J Biol Chem. 2013. PMID: 23935097 Free PMC article.

5

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.

Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. Deacon SW, et al. Chem Biol. 2008 Apr;15(4):322-31. doi: 10.1016/j.chembiol.2008.03.005. Chem Biol. 2008. PMID: 18420139 Free PMC article.

6

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites.

Rennefahrt UE, Deacon SW, Parker SA, Devarajan K, Beeser A, Chernoff J, Knapp S, Turk BE, Peterson JR. Rennefahrt UE, et al. Among authors: deacon sw. J Biol Chem. 2007 May 25;282(21):15667-78. doi: 10.1074/jbc.M700253200. Epub 2007 Mar 28. J Biol Chem. 2007. PMID: 17392278 Free article.

7

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.

Eswaran J, Lee WH, Debreczeni JE, Filippakopoulos P, Turnbull A, Fedorov O, Deacon SW, Peterson JR, Knapp S. Eswaran J, et al. Among authors: deacon sw. Structure. 2007 Feb;15(2):201-13. doi: 10.1016/j.str.2007.01.001. Structure. 2007. PMID: 17292838 Free PMC article.

8

Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.

Nii T, Prabhu VV, Ruvolo V, Madhukar N, Zhao R, Mu H, Heese L, Nishida Y, Kojima K, Garnett MJ, McDermott U, Benes CH, Charter N, Deacon S, Elemento O, Allen JE, Oster W, Stogniew M, Ishizawa J, Andreeff M. Nii T, et al. Among authors: deacon s. Leukemia. 2019 Dec;33(12):2805-2816. doi: 10.1038/s41375-019-0491-z. Epub 2019 May 24. Leukemia. 2019. PMID: 31127149 Free PMC article.

9

Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism.

Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE. Prabhu VV, et al. Among authors: deacon s. Clin Cancer Res. 2019 Apr 1;25(7):2305-2313. doi: 10.1158/1078-0432.CCR-18-2572. Epub 2018 Dec 17. Clin Cancer Res. 2019. PMID: 30559168 Free PMC article.

10

The challenge of selecting protein kinase assays for lead discovery optimization.

Ma H, Deacon S, Horiuchi K. Ma H, et al. Among authors: deacon s. Expert Opin Drug Discov. 2008 Jun;3(6):607-621. doi: 10.1517/17460441.3.6.607. Expert Opin Drug Discov. 2008. PMID: 19662101 Free PMC article.

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