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Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.
J Biol Chem. 2014 Aug 1;289(31):21770-81. doi: 10.1074/jbc.M113.541763. Epub 2014 Jun 19.
J Biol Chem. 2014.
PMID: 24947510
Free PMC article.
Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?
Szendroedi J, Sandtner W, Zarrabi T, Zebedin E, Hilber K, Dudley SC Jr, Fozzard HA, Todt H.
Szendroedi J, et al. Among authors: zarrabi t.
Biophys J. 2007 Dec 15;93(12):4209-24. doi: 10.1529/biophysj.107.104794. Epub 2007 Aug 24.
Biophys J. 2007.
PMID: 17720727
Free PMC article.
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The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.
Cervenka R, Zarrabi T, Lukacs P, Todt H.
Cervenka R, et al. Among authors: zarrabi t.
Mar Drugs. 2010 Apr 21;8(4):1373-93. doi: 10.3390/md8041373.
Mar Drugs. 2010.
PMID: 20479982
Free PMC article.
Review.
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A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.
Zarrabi T, Cervenka R, Sandtner W, Lukacs P, Koenig X, Hilber K, Mille M, Lipkind GM, Fozzard HA, Todt H.
Zarrabi T, et al.
J Biol Chem. 2010 Dec 10;285(50):39458-70. doi: 10.1074/jbc.M110.132886. Epub 2010 Oct 6.
J Biol Chem. 2010.
PMID: 20926383
Free PMC article.
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Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.
Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Sandtner W, Stary-Weinzinger A, Todt H.
Cervenka R, et al. Among authors: zarrabi t.
Sci Rep. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1.
Sci Rep. 2018.
PMID: 29330525
Free PMC article.
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Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.
Sandtner W, Szendroedi J, Zarrabi T, Zebedin E, Hilber K, Glaaser I, Fozzard HA, Dudley SC, Todt H.
Sandtner W, et al. Among authors: zarrabi t.
Mol Pharmacol. 2004 Sep;66(3):648-57. doi: 10.1124/mol.66.3..
Mol Pharmacol. 2004.
PMID: 15322257
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Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels.
Hilber K, Sandtner W, Zarrabi T, Zebedin E, Kudlacek O, Fozzard HA, Todt H.
Hilber K, et al. Among authors: zarrabi t.
Biochemistry. 2005 Oct 25;44(42):13874-82. doi: 10.1021/bi0511944.
Biochemistry. 2005.
PMID: 16229476
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C2C12 skeletal muscle cells adopt cardiac-like sodium current properties in a cardiac cell environment.
Zebedin E, Mille M, Speiser M, Zarrabi T, Sandtner W, Latzenhofer B, Todt H, Hilber K.
Zebedin E, et al. Among authors: zarrabi t.
Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H439-50. doi: 10.1152/ajpheart.00119.2006. Epub 2006 Sep 15.
Am J Physiol Heart Circ Physiol. 2007.
PMID: 16980339
Free article.
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