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Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Minagawa S, et al. Among authors: araya j. Sci Transl Med. 2014 Jun 18;6(241):241ra79. doi: 10.1126/scitranslmed.3008074. Sci Transl Med. 2014. PMID: 24944194 Free PMC article.
Fibrogenic reactions in lung disease.
Araya J, Nishimura SL. Araya J, et al. Annu Rev Pathol. 2010;5:77-98. doi: 10.1146/annurev.pathol.4.110807.092217. Annu Rev Pathol. 2010. PMID: 20078216 Review.
Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.
Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL. Markovics JA, et al. Among authors: araya j. J Biol Chem. 2010 Aug 6;285(32):24695-706. doi: 10.1074/jbc.M110.113977. Epub 2010 Jun 2. J Biol Chem. 2010. PMID: 20519498 Free PMC article.
Recent studies have suggested roles for integrin beta8 in the pathogenesis of chronic obstructive pulmonary disease, brain arteriovenous malformations, and select cancers (Araya, J., Cambier, S., Markovics, J. A., Wolters, P., Jablons, D., Hill, A., Finkbeine …
Recent studies have suggested roles for integrin beta8 in the pathogenesis of chronic obstructive pulmonary disease, brain arteriovenous mal …
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells.
Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. Minagawa S, et al. Among authors: araya j. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L391-401. doi: 10.1152/ajplung.00097.2010. Epub 2010 Dec 17. Am J Physiol Lung Cell Mol Physiol. 2011. PMID: 21224216 Free PMC article.
Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis.
Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. Numata T, et al. Among authors: araya j. J Immunol. 2011 Jul 1;187(1):510-9. doi: 10.4049/jimmunol.1004218. Epub 2011 Jun 6. J Immunol. 2011. PMID: 21646299
Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture.
Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL. Markovics JA, et al. Among authors: araya j. J Biol Chem. 2011 Oct 21;286(42):36864-74. doi: 10.1074/jbc.M111.276790. Epub 2011 Aug 30. J Biol Chem. 2011. PMID: 21878622 Free PMC article.
458 results