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Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract.
Barrera J, Chambliss KL, Ahmed M, Tanigaki K, Thompson B, McDonald JG, Mineo C, Shaul PW. Barrera J, et al. Among authors: tanigaki k. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E345-54. doi: 10.1152/ajpendo.00653.2013. Epub 2014 Jun 17. Am J Physiol Endocrinol Metab. 2014. PMID: 24939737 Free article.
Scavenger receptor class B type I is a plasma membrane cholesterol sensor.
Saddar S, Carriere V, Lee WR, Tanigaki K, Yuhanna IS, Parathath S, Morel E, Warrier M, Sawyer JK, Gerard RD, Temel RE, Brown JM, Connelly M, Mineo C, Shaul PW. Saddar S, et al. Among authors: tanigaki k. Circ Res. 2013 Jan 4;112(1):140-51. doi: 10.1161/CIRCRESAHA.112.280081. Epub 2012 Sep 28. Circ Res. 2013. PMID: 23023567 Free PMC article.
IgG receptor FcγRIIB plays a key role in obesity-induced hypertension.
Sundgren NC, Vongpatanasin W, Boggan BM, Tanigaki K, Yuhanna IS, Chambliss KL, Mineo C, Shaul PW. Sundgren NC, et al. Among authors: tanigaki k. Hypertension. 2015 Feb;65(2):456-62. doi: 10.1161/HYPERTENSIONAHA.114.04670. Epub 2014 Nov 3. Hypertension. 2015. PMID: 25368023 Free PMC article.
Fcγ receptors and ligands and cardiovascular disease.
Tanigaki K, Sundgren N, Khera A, Vongpatanasin W, Mineo C, Shaul PW. Tanigaki K, et al. Circ Res. 2015 Jan 16;116(2):368-84. doi: 10.1161/CIRCRESAHA.116.302795. Circ Res. 2015. PMID: 25593280 Free PMC article. Review.
Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.
Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C. Tanigaki K, et al. J Clin Invest. 2018 Jan 2;128(1):309-322. doi: 10.1172/JCI89333. Epub 2017 Nov 27. J Clin Invest. 2018. PMID: 29202472 Free PMC article.
126 results