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Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract.
Barrera J, Chambliss KL, Ahmed M, Tanigaki K, Thompson B, McDonald JG, Mineo C, Shaul PW. Barrera J, et al. Among authors: shaul pw. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E345-54. doi: 10.1152/ajpendo.00653.2013. Epub 2014 Jun 17. Am J Physiol Endocrinol Metab. 2014. PMID: 24939737 Free article.
ERbeta has nongenomic action in caveolae.
Chambliss KL, Yuhanna IS, Anderson RG, Mendelsohn ME, Shaul PW. Chambliss KL, et al. Among authors: shaul pw. Mol Endocrinol. 2002 May;16(5):938-46. doi: 10.1210/mend.16.5.0827. Mol Endocrinol. 2002. PMID: 11981029
196 results