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Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.
Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M. Zizak M, et al. Among authors: chen t, chen y. J Biol Chem. 2012 Apr 13;287(16):13442-56. doi: 10.1074/jbc.M111.307256. Epub 2012 Feb 27. J Biol Chem. 2012. PMID: 22371496 Free PMC article.
NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells.
Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M. Chen T, et al. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C737-C748. doi: 10.1152/ajpcell.00351.2018. Epub 2019 Jul 31. Am J Physiol Cell Physiol. 2019. PMID: 31365292 Free PMC article.
NHE3 regulatory complexes.
Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X. Donowitz M, et al. J Exp Biol. 2009 Jun;212(Pt 11):1638-46. doi: 10.1242/jeb.028605. J Exp Biol. 2009. PMID: 19448074 Free PMC article. Review.
D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process.
Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, Turner JR, Li X, Kovbasnjuk O, Donowitz M. Lin R, et al. Gastroenterology. 2011 Feb;140(2):560-71. doi: 10.1053/j.gastro.2010.10.042. Epub 2010 Oct 23. Gastroenterology. 2011. PMID: 20977906 Free PMC article.
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