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Malaria drives T cells to exhaustion.
Wykes MN, Horne-Debets JM, Leow CY, Karunarathne DS. Wykes MN, et al. Among authors: karunarathne ds. Front Microbiol. 2014 May 27;5:249. doi: 10.3389/fmicb.2014.00249. eCollection 2014. Front Microbiol. 2014. PMID: 24904561 Free PMC article. Review.
PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.
Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, MacDonald KP, Good MF, Renia L, Ahmed R, Sharpe AH, Wykes MN. Horne-Debets JM, et al. Among authors: karunarathne ds. Cell Rep. 2013 Dec 12;5(5):1204-13. doi: 10.1016/j.celrep.2013.11.002. Epub 2013 Dec 5. Cell Rep. 2013. PMID: 24316071 Free article.
Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.
Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, Yarski M, Poh CM, Lee JS, Cooper MA, Rénia L, Richard D, McCarthy JS, Sharpe AH, Wykes MN. Karunarathne DS, et al. Immunity. 2016 Aug 16;45(2):333-45. doi: 10.1016/j.immuni.2016.07.017. Immunity. 2016. PMID: 27533014 Free article.
A Peptide-Based PD1 Antagonist Enhances T-Cell Priming and Efficacy of a Prophylactic Malaria Vaccine and Promotes Survival in a Lethal Malaria Model.
Phares TW, Kotraiah V, Karunarathne DS, Huang J, Browne CD, Buontempo P, Mansour M, Noe AR, Wykes MN, Pannucci J, Tsuji M, Gutierrez GM. Phares TW, et al. Among authors: karunarathne ds. Front Immunol. 2020 Jul 9;11:1377. doi: 10.3389/fimmu.2020.01377. eCollection 2020. Front Immunol. 2020. PMID: 32733457 Free PMC article.
BRN2 expression increases anoikis resistance in melanoma.
Pierce CJ, Simmons JL, Broit N, Karunarathne D, Ng MF, Boyle GM. Pierce CJ, et al. Oncogenesis. 2020 Jul 6;9(7):64. doi: 10.1038/s41389-020-00247-1. Oncogenesis. 2020. PMID: 32632141 Free PMC article.