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Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction.
Cheng L, Pettersen D, Ohlsson B, Schell P, Karle M, Evertsson E, Pahlén S, Jonforsen M, Plowright AT, Boström J, Fex T, Thelin A, Hilgendorf C, Xue Y, Wahlund G, Lindberg W, Larsson LO, Gustafsson D. Cheng L, et al. Among authors: plowright at. ACS Med Chem Lett. 2014 Feb 18;5(5):538-43. doi: 10.1021/ml400526d. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900876 Free PMC article.
Oxadiazoles in medicinal chemistry.
Boström J, Hogner A, Llinàs A, Wellner E, Plowright AT. Boström J, et al. Among authors: plowright at. J Med Chem. 2012 Mar 8;55(5):1817-30. doi: 10.1021/jm2013248. Epub 2012 Jan 13. J Med Chem. 2012. PMID: 22185670
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallén S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Löfgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Ståhlberg P, Sörme P, Wan H, Wellner E, Oster L. Bengtsson C, et al. Among authors: plowright at. Bioorg Med Chem. 2011 May 15;19(10):3039-53. doi: 10.1016/j.bmc.2011.04.014. Epub 2011 Apr 13. Bioorg Med Chem. 2011. PMID: 21515056
Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases.
Lemurell M, Ulander J, Winiwarter S, Dahlén A, Davidsson Ö, Emtenäs H, Broddefalk J, Swanson M, Hovdal D, Plowright AT, Pettersen A, Rydén-Landergren M, Barlind J, Llinas A, Herslöf M, Drmota T, Sigfridsson K, Moses S, Whatling C. Lemurell M, et al. Among authors: plowright at. J Med Chem. 2015 Jan 22;58(2):897-911. doi: 10.1021/jm501531v. Epub 2014 Dec 22. J Med Chem. 2015. PMID: 25478788
Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.
Pettersen D, Broddefalk J, Emtenäs H, Hayes MA, Lemurell M, Swanson M, Ulander J, Whatling C, Amilon C, Ericsson H, Westin Eriksson A, Granberg K, Plowright AT, Shamovsky I, Dellsèn A, Sundqvist M, Någård M, Lindstedt EL. Pettersen D, et al. Among authors: plowright at. J Med Chem. 2019 May 9;62(9):4312-4324. doi: 10.1021/acs.jmedchem.8b02004. Epub 2019 Mar 26. J Med Chem. 2019. PMID: 30869888
Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors.
Bennett SN, Campbell AD, Hancock A, Johnstone C, Kenny PW, Pickup A, Plowright AT, Selmi N, Simpson I, Stocker A, Whalley DP, Whittamore PR. Bennett SN, et al. Among authors: plowright at. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3511-4. doi: 10.1016/j.bmcl.2010.04.147. Epub 2010 May 5. Bioorg Med Chem Lett. 2010. PMID: 20493691
Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.
Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, Bauer U, Kessler H, Cai M, Hruby VJ, Plowright AT, Craik DJ. Durek T, et al. Among authors: plowright at. J Med Chem. 2018 Apr 26;61(8):3674-3684. doi: 10.1021/acs.jmedchem.8b00170. Epub 2018 Apr 11. J Med Chem. 2018. PMID: 29605997 Free PMC article.
Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.
Durek T, Kaas Q, White AM, Weidmann J, Fuaad AA, Cheneval O, Schroeder CI, de Veer SJ, Dellsén A, Österlund T, Larsson N, Knerr L, Bauer U, Plowright AT, Craik DJ. Durek T, et al. Among authors: plowright at. J Med Chem. 2021 Jul 22;64(14):9906-9915. doi: 10.1021/acs.jmedchem.1c00095. Epub 2021 Jul 1. J Med Chem. 2021. PMID: 34197114
Medicinal Chemistry Approaches to Heart Regeneration.
Schade D, Plowright AT. Schade D, et al. Among authors: plowright at. J Med Chem. 2015 Dec 24;58(24):9451-79. doi: 10.1021/acs.jmedchem.5b00446. Epub 2015 Sep 3. J Med Chem. 2015. PMID: 26288266 Review.
46 results