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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295.
Qian X, McDonald A, Zhou HJ, Adams ND, Parrish CA, Duffy KJ, Fitch DM, Tedesco R, Ashcraft LW, Yao B, Jiang H, Huang JK, Marin MV, Aroyan CE, Wang J, Ahmed S, Burgess JL, Chaudhari AM, Donatelli CA, Darcy MG, Ridgers LH, Newlander KA, Schmidt SJ, Chai D, Colón M, Zimmerman MN, Lad L, Sakowicz R, Schauer S, Belmont L, Baliga R, Pierce DW, Finer JT, Wang Z, Morgan BP, Morgans DJ Jr, Auger KR, Sung CM, Carson JD, Luo L, Hugger ED, Copeland RA, Sutton D, Elliott JD, Jackson JR, Wood KW, Dhanak D, Bergnes G, Knight SD. Qian X, et al. Among authors: jiang h. ACS Med Chem Lett. 2010 Jan 19;1(1):30-4. doi: 10.1021/ml900018m. eCollection 2010 Apr 8. ACS Med Chem Lett. 2010. PMID: 24900171 Free PMC article.
Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin.
Morgan BP, Muci A, Lu PP, Qian X, Tochimoto T, Smith WW, Garard M, Kraynack E, Collibee S, Suehiro I, Tomasi A, Valdez SC, Wang W, Jiang H, Hartman J, Rodriguez HM, Kawas R, Sylvester S, Elias KA, Godinez G, Lee K, Anderson R, Sueoka S, Xu D, Wang Z, Djordjevic N, Malik FI, Morgans DJ Jr. Morgan BP, et al. Among authors: jiang h. ACS Med Chem Lett. 2010 Aug 20;1(9):472-7. doi: 10.1021/ml100138q. eCollection 2010 Dec 9. ACS Med Chem Lett. 2010. PMID: 24900233 Free PMC article.
Discovery of Novel N-(5-(Pyridin-3-yl)-1H-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease.
Yang B, Zhang H, Li N, Gao L, Jiang H, Kan W, Yuan H, Li J, Zhao D, Xiong B, Zhou Y, Guo D, Liu T. Yang B, et al. Among authors: jiang h. J Med Chem. 2022 Dec 8;65(23):15770-15788. doi: 10.1021/acs.jmedchem.2c01334. Epub 2022 Nov 17. J Med Chem. 2022. PMID: 36384292
Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer.
Wu F, Cheng G, Yao Y, Kogiso M, Jiang H, Li XN, Song Y. Wu F, et al. Among authors: jiang h. Med Chem. 2018;14(7):715-724. doi: 10.2174/1573406414666180524093659. Med Chem. 2018. PMID: 29792149 Free PMC article.
DTI-ALPS index decreased in patients with Type 2 Diabetes Mellitus.
Yu S, Jiang H, Yu L, Liu T, Yang C, Cao J, Song Q, Miao Y, Wang W. Yu S, et al. Among authors: jiang h. Front Neurosci. 2024 May 22;18:1383780. doi: 10.3389/fnins.2024.1383780. eCollection 2024. Front Neurosci. 2024. PMID: 38841097 Free PMC article.
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