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WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.
Anastas JN, Kulikauskas RM, Tamir T, Rizos H, Long GV, von Euw EM, Yang PT, Chen HW, Haydu L, Toroni RA, Lucero OM, Chien AJ, Moon RT. Anastas JN, et al. Among authors: chen hw. J Clin Invest. 2014 Jul;124(7):2877-90. doi: 10.1172/JCI70156. Epub 2014 May 27. J Clin Invest. 2014. PMID: 24865425 Free PMC article.
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.
Ploper D, Taelman VF, Robert L, Perez BS, Titz B, Chen HW, Graeber TG, von Euw E, Ribas A, De Robertis EM. Ploper D, et al. Among authors: chen hw. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E420-9. doi: 10.1073/pnas.1424576112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605940 Free PMC article.
PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity.
Logan JE, Mostofizadeh N, Desai AJ, VON Euw E, Conklin D, Konkankit V, Hamidi H, Eckardt M, Anderson L, Chen HW, Ginther C, Taschereau E, Bui PH, Christensen JG, Belldegrun AS, Slamon DJ, Kabbinavar FF. Logan JE, et al. Among authors: chen hw. Anticancer Res. 2013 Aug;33(8):2997-3004. Anticancer Res. 2013. PMID: 23898052
1,662 results