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Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI. Madiraju AK, et al. Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23. Nat Med. 2018. PMID: 30038219 Free PMC article.
Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.
Cantley JL, Vatner DF, Galbo T, Madiraju A, Petersen M, Perry RJ, Kumashiro N, Guebre-Egziabher F, Gattu AK, Stacy MR, Dione DP, Sinusas AJ, Ragolia L, Hall CE, Manchem VP, Bhanot S, Bogan JS, Samuel VT. Cantley JL, et al. Among authors: madiraju a. Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E773-83. doi: 10.1152/ajpendo.00148.2014. Epub 2014 Aug 26. Am J Physiol Endocrinol Metab. 2014. PMID: 25159329 Free PMC article.
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance.
Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI. Petersen MC, et al. Among authors: madiraju ak. J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct 17. J Clin Invest. 2016. PMID: 27760050 Free PMC article.
Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.
Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. Jesinkey SR, et al. Among authors: madiraju ak. Cell Rep. 2019 Jul 16;28(3):759-772.e10. doi: 10.1016/j.celrep.2019.06.058. Cell Rep. 2019. PMID: 31315053 Free PMC article.