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B-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity.
González-Ruiz V, Pascua I, Fernández-Marcelo T, Ribelles P, Bianchini G, Sridharan V, Iniesta P, Ramos MT, Olives AI, Martín MA, Menéndez JC. González-Ruiz V, et al. Among authors: pascua i. PLoS One. 2014 May 15;9(5):e95998. doi: 10.1371/journal.pone.0095998. eCollection 2014. PLoS One. 2014. PMID: 24830682 Free PMC article.
Methylation profiling in non-small cell lung cancer: clinical implications.
Morán A, Fernández-Marcelo T, Carro J, De Juan C, Pascua I, Head J, Gómez A, Hernando F, Torres AJ, Benito M, Iniesta P. Morán A, et al. Among authors: pascua i. Int J Oncol. 2012 Mar;40(3):739-46. doi: 10.3892/ijo.2011.1253. Epub 2011 Nov 7. Int J Oncol. 2012. PMID: 22076605
Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity.
Fernández-Marcelo T, Frías C, Pascua I, de Juan C, Head J, Gómez A, Hernando F, Jarabo JR, Díaz-Rubio E, Torres AJ, Rouleau M, Benito M, Iniesta P. Fernández-Marcelo T, et al. Among authors: pascua i. J Exp Clin Cancer Res. 2014 Feb 15;33(1):19. doi: 10.1186/1756-9966-33-19. J Exp Clin Cancer Res. 2014. PMID: 24528514 Free PMC article.
Differential expression of senescence and cell death factors in non-small cell lung and colorectal tumors showing telomere attrition.
Fernández-Marcelo T, Morán A, de Juan C, Pascua I, Head J, Gómez A, Hernando F, López-Asenjo JA, Hernández S, Sánchez-Pernaute A, Torres AJ, Benito M, Iniesta P. Fernández-Marcelo T, et al. Among authors: pascua i. Oncology. 2012;82(3):153-64. doi: 10.1159/000335678. Epub 2012 Mar 15. Oncology. 2012. PMID: 22433385