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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. Chin RM, et al. Among authors: trauger sa. Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14. Nature. 2014. PMID: 24828042 Free PMC article.
Data-driven synthesis of proteolysis-resistant peptide hormones.
Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Prothiwa M, et al. Among authors: trauger sa. J Am Chem Soc. 2014 Dec 24;136(51):17710-3. doi: 10.1021/ja5065735. Epub 2014 Dec 12. J Am Chem Soc. 2014. PMID: 25496053
Metabolic oxidation regulates embryonic stem cell differentiation.
Yanes O, Clark J, Wong DM, Patti GJ, Sánchez-Ruiz A, Benton HP, Trauger SA, Desponts C, Ding S, Siuzdak G. Yanes O, et al. Among authors: trauger sa. Nat Chem Biol. 2010 Jun;6(6):411-7. doi: 10.1038/nchembio.364. Epub 2010 May 2. Nat Chem Biol. 2010. PMID: 20436487 Free PMC article.
How the glycosyltransferase OGT catalyzes amide bond cleavage.
Janetzko J, Trauger SA, Lazarus MB, Walker S. Janetzko J, et al. Among authors: trauger sa. Nat Chem Biol. 2016 Nov;12(11):899-901. doi: 10.1038/nchembio.2173. Epub 2016 Sep 12. Nat Chem Biol. 2016. PMID: 27618188 Free PMC article.
Microbial metalloproteomes are largely uncharacterized.
Cvetkovic A, Menon AL, Thorgersen MP, Scott JW, Poole FL 2nd, Jenney FE Jr, Lancaster WA, Praissman JL, Shanmukh S, Vaccaro BJ, Trauger SA, Kalisiak E, Apon JV, Siuzdak G, Yannone SM, Tainer JA, Adams MW. Cvetkovic A, et al. Among authors: trauger sa. Nature. 2010 Aug 5;466(7307):779-82. doi: 10.1038/nature09265. Epub 2010 Jul 18. Nature. 2010. PMID: 20639861
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Mayo L, et al. Among authors: trauger sa. Nat Med. 2014 Oct;20(10):1147-56. doi: 10.1038/nm.3681. Epub 2014 Sep 14. Nat Med. 2014. PMID: 25216636 Free PMC article.
METLIN: a metabolite mass spectral database.
Smith CA, O'Maille G, Want EJ, Qin C, Trauger SA, Brandon TR, Custodio DE, Abagyan R, Siuzdak G. Smith CA, et al. Among authors: trauger sa. Ther Drug Monit. 2005 Dec;27(6):747-51. doi: 10.1097/01.ftd.0000179845.53213.39. Ther Drug Monit. 2005. PMID: 16404815
70 results