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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. Chin RM, et al. Among authors: petrascheck m. Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14. Nature. 2014. PMID: 24828042 Free PMC article.
Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans.
Gomez-Amaro RL, Valentine ER, Carretero M, LeBoeuf SE, Rangaraju S, Broaddus CD, Solis GM, Williamson JR, Petrascheck M. Gomez-Amaro RL, et al. Among authors: petrascheck m. Genetics. 2015 Jun;200(2):443-54. doi: 10.1534/genetics.115.175851. Epub 2015 Apr 21. Genetics. 2015. PMID: 25903497 Free PMC article.
C. elegans as Model for Drug Discovery.
Carretero M, Solis GM, Petrascheck M. Carretero M, et al. Among authors: petrascheck m. Curr Top Med Chem. 2017;17(18):2067-2076. doi: 10.2174/1568026617666170131114401. Curr Top Med Chem. 2017. PMID: 28137208 Review.
The mitochondrial ATP synthase is a shared drug target for aging and dementia.
Goldberg J, Currais A, Prior M, Fischer W, Chiruta C, Ratliff E, Daugherty D, Dargusch R, Finley K, Esparza-Moltó PB, Cuezva JM, Maher P, Petrascheck M, Schubert D. Goldberg J, et al. Among authors: petrascheck m. Aging Cell. 2018 Apr;17(2):e12715. doi: 10.1111/acel.12715. Epub 2018 Jan 7. Aging Cell. 2018. PMID: 29316249 Free PMC article.
37 results