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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. Chin RM, et al. Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14. Nature. 2014. PMID: 24828042 Free PMC article.
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. Fu X, et al. Among authors: chin rm. Cell Metab. 2015 Sep 1;22(3):508-15. doi: 10.1016/j.cmet.2015.06.009. Epub 2015 Jul 16. Cell Metab. 2015. PMID: 26190651 Free PMC article.
Target identification using drug affinity responsive target stability (DARTS).
Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J. Lomenick B, et al. Among authors: chin rm. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21984-9. doi: 10.1073/pnas.0910040106. Epub 2009 Dec 7. Proc Natl Acad Sci U S A. 2009. PMID: 19995983 Free PMC article.
Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models.
Chin RM, Rakhit R, Ditsworth D, Wang C, Bartholomeus J, Liu S, Mody A, Laishu A, Eastes A, Tai C, Kim RY, Li J, Hansberry S, Khasnavis S, Rafalski V, Herendeen D, Garda V, Phung J, de Roulet D, Ordureau A, Harper JW, Johnstone S, Stöhr J, Hertz NT. Chin RM, et al. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528378. doi: 10.1101/2023.02.14.528378. bioRxiv. 2023. PMID: 36824886 Free PMC article. Preprint.
Silylation of Pyridine, Picolines, and Quinoline with a Zinc Catalyst.
Prybil JW, Wallace R, Warren A, Klingman J, Vaillant R, Hall MB, Yang X, Brennessel WW, Chin RM. Prybil JW, et al. Among authors: chin rm. ACS Omega. 2020 Jan 10;5(3):1528-1539. doi: 10.1021/acsomega.9b03317. eCollection 2020 Jan 28. ACS Omega. 2020. PMID: 32010826 Free PMC article.
13 results