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Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells.
Sano T, Kagawa M, Okuno M, Ishibashi N, Hashimoto M, Yamamoto M, Suzuki R, Kohno H, Matsushima-Nishiwaki R, Takano Y, Tsurumi H, Kojima S, Friedman SL, Moriwaki H, Tanaka T. Sano T, et al. Among authors: tanaka t. Nutr Cancer. 2005;51(2):197-206. doi: 10.1207/s15327914nc5102_10. Nutr Cancer. 2005. PMID: 15860442
Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development.
Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H, Tanaka T, Fausto N, Kaneko S. Okada H, et al. Among authors: tanaka t. Cancer Res. 2012 Sep 1;72(17):4459-71. doi: 10.1158/0008-5472.CAN-12-0028. Epub 2012 May 31. Cancer Res. 2012. PMID: 22651928
Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice.
Terakura D, Shimizu M, Iwasa J, Baba A, Kochi T, Ohno T, Kubota M, Shirakami Y, Shiraki M, Takai K, Tsurumi H, Tanaka T, Moriwaki H. Terakura D, et al. Among authors: tanaka t. Carcinogenesis. 2012 Dec;33(12):2499-506. doi: 10.1093/carcin/bgs303. Epub 2012 Oct 1. Carcinogenesis. 2012. PMID: 23027617
Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model.
Takegoshi K, Honda M, Okada H, Takabatake R, Matsuzawa-Nagata N, Campbell JS, Nishikawa M, Shimakami T, Shirasaki T, Sakai Y, Yamashita T, Takamura T, Tanaka T, Kaneko S. Takegoshi K, et al. Among authors: tanaka t. Oncotarget. 2017 Mar 14;8(11):18191-18205. doi: 10.18632/oncotarget.15304. Oncotarget. 2017. PMID: 28212548 Free PMC article.
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