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Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent.
Jin CH, Krishnaiah M, Sreenu D, Subrahmanyam VB, Rao KS, Lee HJ, Park SJ, Park HJ, Lee K, Sheen YY, Kim DK. Jin CH, et al. Among authors: lee k, lee hj. J Med Chem. 2014 May 22;57(10):4213-38. doi: 10.1021/jm500115w. Epub 2014 May 13. J Med Chem. 2014. PMID: 24786585
Discovery of (E)-3-(3-((2-Cyano-4'-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis.
Shim S, Krishnaiah M, Sankham MR, Kim I, Lee Y, Shin I, Oh AR, Lee HJ, Vu TNL, Park J, Choi S, Park S, Kwon Y, Fang S, Kim DK. Shim S, et al. Among authors: lee y, lee hj. J Med Chem. 2022 Jul 28;65(14):9974-10000. doi: 10.1021/acs.jmedchem.2c00641. Epub 2022 Jul 7. J Med Chem. 2022. PMID: 35797110
A micellar prodrug of paclitaxel conjugated to cyclotriphosphazene.
Jun YJ, Min JH, Ji da E, Yoo JH, Kim JH, Lee HJ, Jeong B, Sohn YS. Jun YJ, et al. Among authors: lee hj. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6410-3. doi: 10.1016/j.bmcl.2008.10.077. Epub 2008 Oct 22. Bioorg Med Chem Lett. 2008. PMID: 18990574
A novel micelle-encapsulated platinum(II) anticancer agent.
Jadhav VB, Jun YJ, Song JH, Park MK, Oh JH, Chae SW, Kim IS, Choi SJ, Lee HJ, Sohn YS. Jadhav VB, et al. Among authors: lee hj. J Control Release. 2010 Oct 1;147(1):144-50. doi: 10.1016/j.jconrel.2010.07.101. Epub 2010 Jul 21. J Control Release. 2010. PMID: 20654662
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