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4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-β type I receptor kinase.
Jin CH, Krishnaiah M, Sreenu D, Subrahmanyam VB, Park HJ, Park SJ, Sheen YY, Kim DK. Jin CH, et al. Among authors: park sj, park hj. Bioorg Med Chem. 2014 May 1;22(9):2724-32. doi: 10.1016/j.bmc.2014.03.022. Epub 2014 Mar 21. Bioorg Med Chem. 2014. PMID: 24704197
Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent.
Jin CH, Krishnaiah M, Sreenu D, Subrahmanyam VB, Rao KS, Lee HJ, Park SJ, Park HJ, Lee K, Sheen YY, Kim DK. Jin CH, et al. Among authors: park sj, park hj. J Med Chem. 2014 May 22;57(10):4213-38. doi: 10.1021/jm500115w. Epub 2014 May 13. J Med Chem. 2014. PMID: 24786585
Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors.
Jo DH, An H, Chang DJ, Baek YY, Cho CS, Jun HO, Park SJ, Kim JH, Lee HY, Kim KW, Lee J, Park HJ, Kim YM, Suh YG, Kim JH. Jo DH, et al. Among authors: park sj, park hj. J Mol Med (Berl). 2014 Oct;92(10):1083-92. doi: 10.1007/s00109-014-1168-8. Epub 2014 May 31. J Mol Med (Berl). 2014. PMID: 24875598
8,205 results