Lefkowitz RJ - Search Results

1

Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).

Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Strachan RT, et al. Among authors: lefkowitz rj. J Biol Chem. 2014 May 16;289(20):14211-24. doi: 10.1074/jbc.M114.548131. Epub 2014 Mar 25. J Biol Chem. 2014. PMID: 24668815 Free PMC article.

2

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

Cotecchia S, Ostrowski J, Kjelsberg MA, Caron MG, Lefkowitz RJ. Cotecchia S, et al. Among authors: lefkowitz rj. J Biol Chem. 1992 Jan 25;267(3):1633-9. J Biol Chem. 1992. PMID: 1309789 Free article.

3

Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.

Liggett SB, Ostrowski J, Chesnut LC, Kurose H, Raymond JR, Caron MG, Lefkowitz RJ. Liggett SB, et al. Among authors: lefkowitz rj. J Biol Chem. 1992 Mar 5;267(7):4740-6. J Biol Chem. 1992. PMID: 1311318 Free article.

4

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ. Attramadal H, et al. Among authors: lefkowitz rj. J Biol Chem. 1992 Sep 5;267(25):17882-90. J Biol Chem. 1992. PMID: 1517224 Free article.

5

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

Lomasney JW, Cotecchia S, Lorenz W, Leung WY, Schwinn DA, Yang-Feng TL, Brownstein M, Lefkowitz RJ, Caron MG. Lomasney JW, et al. Among authors: lefkowitz rj. J Biol Chem. 1991 Apr 5;266(10):6365-9. J Biol Chem. 1991. PMID: 1706716 Free article.

6

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.

Inglese J, Glickman JF, Lorenz W, Caron MG, Lefkowitz RJ. Inglese J, et al. Among authors: lefkowitz rj. J Biol Chem. 1992 Jan 25;267(3):1422-5. J Biol Chem. 1992. PMID: 1730692 Free article.

7

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.

Schwinn DA, Lomasney JW, Lorenz W, Szklut PJ, Fremeau RT Jr, Yang-Feng TL, Caron MG, Lefkowitz RJ, Cotecchia S. Schwinn DA, et al. Among authors: lefkowitz rj. J Biol Chem. 1990 May 15;265(14):8183-9. J Biol Chem. 1990. PMID: 1970822 Free article.

8

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.

Cotecchia S, Kobilka BK, Daniel KW, Nolan RD, Lapetina EY, Caron MG, Lefkowitz RJ, Regan JW. Cotecchia S, et al. Among authors: lefkowitz rj. J Biol Chem. 1990 Jan 5;265(1):63-9. J Biol Chem. 1990. PMID: 2152928 Free article.

9

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

Hausdorff WP, Hnatowich M, O'Dowd BF, Caron MG, Lefkowitz RJ. Hausdorff WP, et al. Among authors: lefkowitz rj. J Biol Chem. 1990 Jan 25;265(3):1388-93. J Biol Chem. 1990. PMID: 2153131 Free article.

10

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Lohse MJ, et al. Among authors: lefkowitz rj. J Biol Chem. 1990 Feb 25;265(6):3202-11. J Biol Chem. 1990. PMID: 2154473 Free article.

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