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Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.
Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH. Zheng N, et al. Among authors: mcintosh jm. J Med Chem. 2021 Jul 8;64(13):9513-9524. doi: 10.1021/acs.jmedchem.1c00802. Epub 2021 Jun 23. J Med Chem. 2021. PMID: 34161094 Free PMC article.
Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.
Zheng G, Zhang Z, Dowell C, Wala E, Dwoskin LP, Holtman JR, McIntosh JM, Crooks PA. Zheng G, et al. Among authors: mcintosh jm. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2476-9. doi: 10.1016/j.bmcl.2011.02.043. Epub 2011 Feb 23. Bioorg Med Chem Lett. 2011. PMID: 21397497 Free PMC article.
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.
Bavo F, Pucci S, Fasoli F, Lammi C, Moretti M, Mucchietto V, Lattuada D, Viani P, De Palma C, Budriesi R, Corradini I, Dowell C, McIntosh JM, Clementi F, Bolchi C, Gotti C, Pallavicini M. Bavo F, et al. Among authors: mcintosh jm. J Med Chem. 2018 Dec 13;61(23):10531-10544. doi: 10.1021/acs.jmedchem.8b01052. Epub 2018 Nov 26. J Med Chem. 2018. PMID: 30403486
327 results