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Evaluation of the safety and biodistribution of M032, an attenuated herpes simplex virus type 1 expressing hIL-12, after intracerebral administration to aotus nonhuman primates.
Roth JC, Cassady KA, Cody JJ, Parker JN, Price KH, Coleman JM, Peggins JO, Noker PE, Powers NW, Grimes SD, Carroll SL, Gillespie GY, Whitley RJ, Markert JM. Roth JC, et al. Among authors: gillespie gy. Hum Gene Ther Clin Dev. 2014 Mar;25(1):16-27. doi: 10.1089/humc.2013.201. Hum Gene Ther Clin Dev. 2014. PMID: 24649838 Free PMC article.
Serial passage through human glioma xenografts selects for a Deltagamma134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumors.
Shah AC, Price KH, Parker JN, Samuel SL, Meleth S, Cassady KA, Gillespie GY, Whitley RJ, Markert JM. Shah AC, et al. Among authors: gillespie gy. J Virol. 2006 Aug;80(15):7308-15. doi: 10.1128/JVI.00725-06. J Virol. 2006. PMID: 16840311 Free PMC article.
Herpes simplex virus oncolytic therapy for pediatric malignancies.
Friedman GK, Pressey JG, Reddy AT, Markert JM, Gillespie GY. Friedman GK, et al. Among authors: gillespie gy. Mol Ther. 2009 Jul;17(7):1125-35. doi: 10.1038/mt.2009.73. Epub 2009 Apr 14. Mol Ther. 2009. PMID: 19367259 Free PMC article. Review.
A phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses.
Markert JM, Razdan SN, Kuo HC, Cantor A, Knoll A, Karrasch M, Nabors LB, Markiewicz M, Agee BS, Coleman JM, Lakeman AD, Palmer CA, Parker JN, Whitley RJ, Weichselbaum RR, Fiveash JB, Gillespie GY. Markert JM, et al. Among authors: gillespie gy. Mol Ther. 2014 May;22(5):1048-55. doi: 10.1038/mt.2014.22. Epub 2014 Feb 27. Mol Ther. 2014. PMID: 24572293 Free PMC article. Clinical Trial.
Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma.
Patel DM, Foreman PM, Nabors LB, Riley KO, Gillespie GY, Markert JM. Patel DM, et al. Among authors: gillespie gy. Hum Gene Ther Clin Dev. 2016 Jun;27(2):69-78. doi: 10.1089/humc.2016.031. Hum Gene Ther Clin Dev. 2016. PMID: 27314913 Free PMC article. Clinical Trial.
Rationale and Design of a Phase 1 Clinical Trial to Evaluate HSV G207 Alone or with a Single Radiation Dose in Children with Progressive or Recurrent Malignant Supratentorial Brain Tumors.
Waters AM, Johnston JM, Reddy AT, Fiveash J, Madan-Swain A, Kachurak K, Bag AK, Gillespie GY, Markert JM, Friedman GK. Waters AM, et al. Among authors: gillespie gy. Hum Gene Ther Clin Dev. 2017 Mar;28(1):7-16. doi: 10.1089/humc.2017.002. Hum Gene Ther Clin Dev. 2017. PMID: 28319448 Free PMC article. Clinical Trial.
Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice.
Bernstock JD, Vicario N, Li R, Nan L, Totsch SK, Schlappi C, Gessler F, Han X, Parenti R, Beierle EA, Whitley RJ, Aban I, Gillespie GY, Markert JM, Friedman GK. Bernstock JD, et al. Among authors: gillespie gy. Cancer Gene Ther. 2020 Apr;27(3-4):246-255. doi: 10.1038/s41417-019-0091-0. Epub 2019 Mar 28. Cancer Gene Ther. 2020. PMID: 30918335 Free PMC article.
295 results