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1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood-brain barrier.
Prinz M, Parlar S, Bayraktar G, Alptüzün V, Erciyas E, Fallarero A, Karlsson D, Vuorela P, Burek M, Förster C, Turunc E, Armagan G, Yalcin A, Schiller C, Leuner K, Krug M, Sotriffer CA, Holzgrabe U. Prinz M, et al. Among authors: holzgrabe u. Eur J Pharm Sci. 2013 Jul 16;49(4):603-13. doi: 10.1016/j.ejps.2013.04.024. Epub 2013 May 2. Eur J Pharm Sci. 2013. PMID: 23643737
Anti-trypanosomal activities and structural chemical properties of selected compound classes.
Ponte-Sucre A, Bruhn H, Schirmeister T, Cecil A, Albert CR, Buechold C, Tischer M, Schlesinger S, Goebel T, Fuß A, Mathein D, Merget B, Sotriffer CA, Stich A, Krohne G, Engstler M, Bringmann G, Holzgrabe U. Ponte-Sucre A, et al. Among authors: holzgrabe u. Parasitol Res. 2015 Feb;114(2):501-12. doi: 10.1007/s00436-014-4210-4. Epub 2014 Nov 23. Parasitol Res. 2015. PMID: 25416330
Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei.
Seufert F, Kuhn M, Hein M, Weiwad M, Vivoli M, Norville IH, Sarkar-Tyson M, Marshall LE, Schweimer K, Bruhn H, Rösch P, Harmer NJ, Sotriffer CA, Holzgrabe U. Seufert F, et al. Among authors: holzgrabe u. Bioorg Med Chem. 2016 Nov 1;24(21):5134-5147. doi: 10.1016/j.bmc.2016.08.025. Epub 2016 Aug 20. Bioorg Med Chem. 2016. PMID: 27591009
A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy.
Agnetta L, Kauk M, Canizal MCA, Messerer R, Holzgrabe U, Hoffmann C, Decker M. Agnetta L, et al. Among authors: holzgrabe u. Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7282-7287. doi: 10.1002/anie.201701524. Epub 2017 May 16. Angew Chem Int Ed Engl. 2017. PMID: 28510314
456 results