Decker M - Search Results

1

Acetylcholinesterase inhibitors with photoswitchable inhibition of β-amyloid aggregation.

Chen X, Wehle S, Kuzmanovic N, Merget B, Holzgrabe U, König B, Sotriffer CA, Decker M. Chen X, et al. Among authors: decker m. ACS Chem Neurosci. 2014 May 21;5(5):377-89. doi: 10.1021/cn500016p. Epub 2014 Mar 14. ACS Chem Neurosci. 2014. PMID: 24628027 Free PMC article.

2

Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine.

Decker M. Decker M. Eur J Med Chem. 2005 Mar;40(3):305-13. doi: 10.1016/j.ejmech.2004.12.003. Eur J Med Chem. 2005. PMID: 15725500

3

Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase.

Decker M, Krauth F, Lehmann J. Decker M, et al. Bioorg Med Chem. 2006 Mar 15;14(6):1966-77. doi: 10.1016/j.bmc.2005.10.044. Epub 2005 Nov 11. Bioorg Med Chem. 2006. PMID: 16289855

4

Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.

Decker M, Kraus B, Heilmann J. Decker M, et al. Bioorg Med Chem. 2008 Apr 15;16(8):4252-61. doi: 10.1016/j.bmc.2008.02.083. Epub 2008 Feb 29. Bioorg Med Chem. 2008. PMID: 18343673

5

Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.

Chen X, Tikhonova IG, Decker M. Chen X, et al. Among authors: decker m. Bioorg Med Chem. 2011 Feb 1;19(3):1222-35. doi: 10.1016/j.bmc.2010.12.034. Epub 2010 Dec 21. Bioorg Med Chem. 2011. PMID: 21232964

6

Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.

Macabeo AP, Vidar WS, Chen X, Decker M, Heilmann J, Wan B, Franzblau SG, Galvez EV, Aguinaldo MA, Cordell GA. Macabeo AP, et al. Among authors: decker m. Eur J Med Chem. 2011 Jul;46(7):3118-23. doi: 10.1016/j.ejmech.2011.04.025. Epub 2011 Apr 19. Eur J Med Chem. 2011. PMID: 21546135

7

Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.

Chen X, Zenger K, Lupp A, Kling B, Heilmann J, Fleck C, Kraus B, Decker M. Chen X, et al. Among authors: decker m. J Med Chem. 2012 Jun 14;55(11):5231-42. doi: 10.1021/jm300246n. Epub 2012 May 24. J Med Chem. 2012. PMID: 22624880

8

Multi-target compounds acting in the central nervous system designed from natural products.

Chen X, Decker M. Chen X, et al. Among authors: decker m. Curr Med Chem. 2013;20(13):1673-85. doi: 10.2174/0929867311320130007. Curr Med Chem. 2013. PMID: 23410166 Review.

9

In-vitro stability and metabolism of a tacrine-silibinin codrug.

Zenger K, Chen X, Decker M, Kraus B. Zenger K, et al. Among authors: decker m. J Pharm Pharmacol. 2013 Dec;65(12):1765-72. doi: 10.1111/jphp.12070. Epub 2013 Apr 29. J Pharm Pharmacol. 2013. PMID: 24236987

10

Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.

Darras FH, Pockes S, Huang G, Wehle S, Strasser A, Wittmann HJ, Nimczick M, Sotriffer CA, Decker M. Darras FH, et al. Among authors: decker m. ACS Chem Neurosci. 2014 Mar 19;5(3):225-42. doi: 10.1021/cn4002126. Epub 2014 Jan 14. ACS Chem Neurosci. 2014. PMID: 24422467 Free PMC article.

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