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Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism.
Tan S, Santolaya JL, Wright TF, Liu Q, Fujikawa T, Chi S, Bergstrom CP, Lopez A, Chen Q, Vale G, McDonald JG, Schmidt A, Vo N, Kim J, Baniasadi H, Li L, Zhu G, He TC, Zhan X, Obata Y, Jin A, Jia D, Elmquist JK, Sifuentes-Dominguez L, Burstein E. Tan S, et al. Among authors: mcdonald jg. Nat Metab. 2024 May 22. doi: 10.1038/s42255-024-01044-5. Online ahead of print. Nat Metab. 2024. PMID: 38777856
Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating Jmjd3.
Salloum Z, Dauner K, Li YF, Verma N, Valdivieso-González D, Almendro-Vedia VG, Zhang JD, Nakka K, Chen MX, McDonald JG, Corley CD, Sorisky A, Song BL, López-Montero I, Luo J, Dilworth JF, Zha X. Salloum Z, et al. Among authors: mcdonald jg. Elife. 2024 Apr 11;13:e85964. doi: 10.7554/eLife.85964. Online ahead of print. Elife. 2024. PMID: 38602170 Free article.
Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension.
Harvey LD, Alotaibi M, Kim HJ, Tai YY, Tang Y, Sun W, El Khoury W, Woodcock CC, Aaraj YA, St Croix CM, Stolz DB, Lee J, Cheng MH, Schwantes-An TH, Desai AA, Pauciulo MW, Nichols WC, Webb A, Lafyatis R, Nouraie M, Wu H, McDonald JG, Chauvet C, Cheng S, Bahar I, Bertero T, Benza RL, Jain M, Chan SY. Harvey LD, et al. Among authors: mcdonald jg. bioRxiv [Preprint]. 2024 Mar 1:2024.02.26.582142. doi: 10.1101/2024.02.26.582142. bioRxiv. 2024. PMID: 38464060 Free PMC article. Preprint.
DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time.
Relovska S, Wang H, Zhang X, Fernández-Tussy P, Jeong KJ, Choi J, Suárez Y, McDonald JG, Fernández-Hernando C, Chung JJ. Relovska S, et al. Among authors: mcdonald jg. bioRxiv [Preprint]. 2024 Feb 11:2023.12.21.572851. doi: 10.1101/2023.12.21.572851. bioRxiv. 2024. PMID: 38187697 Free PMC article. Preprint.
130 results