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Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
Ciceri P, Müller S, O'Mahony A, Fedorov O, Filippakopoulos P, Hunt JP, Lasater EA, Pallares G, Picaud S, Wells C, Martin S, Wodicka LM, Shah NP, Treiber DK, Knapp S. Ciceri P, et al. Among authors: shah np. Nat Chem Biol. 2014 Apr;10(4):305-12. doi: 10.1038/nchembio.1471. Epub 2014 Mar 2. Nat Chem Biol. 2014. PMID: 24584101 Free PMC article.
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.
Carter TA, Wodicka LM, Shah NP, Velasco AM, Fabian MA, Treiber DK, Milanov ZV, Atteridge CE, Biggs WH 3rd, Edeen PT, Floyd M, Ford JM, Grotzfeld RM, Herrgard S, Insko DE, Mehta SA, Patel HK, Pao W, Sawyers CL, Varmus H, Zarrinkar PP, Lockhart DJ. Carter TA, et al. Among authors: shah np. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11011-6. doi: 10.1073/pnas.0504952102. Epub 2005 Jul 26. Proc Natl Acad Sci U S A. 2005. PMID: 16046538 Free PMC article.
Ins and outs of kinase DFG motifs.
Treiber DK, Shah NP. Treiber DK, et al. Among authors: shah np. Chem Biol. 2013 Jun 20;20(6):745-6. doi: 10.1016/j.chembiol.2013.06.001. Chem Biol. 2013. PMID: 23790484
MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction.
Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP. Asmussen J, et al. Among authors: shah np. Cancer Discov. 2014 Feb;4(2):200-15. doi: 10.1158/2159-8290.CD-13-0235. Epub 2013 Dec 20. Cancer Discov. 2014. PMID: 24362263 Free PMC article.
Crenolanib is a selective type I pan-FLT3 inhibitor.
Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP. Smith CC, et al. Among authors: shah np. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24. doi: 10.1073/pnas.1320661111. Epub 2014 Mar 12. Proc Natl Acad Sci U S A. 2014. PMID: 24623852 Free PMC article.
402 results