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Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death.
Van der Donckt C, Van Herck JL, Schrijvers DM, Vanhoutte G, Verhoye M, Blockx I, Van Der Linden A, Bauters D, Lijnen HR, Sluimer JC, Roth L, Van Hove CE, Fransen P, Knaapen MW, Hervent AS, De Keulenaer GW, Bult H, Martinet W, Herman AG, De Meyer GR. Van der Donckt C, et al. Among authors: sluimer jc. Eur Heart J. 2015 May 1;36(17):1049-58. doi: 10.1093/eurheartj/ehu041. Epub 2014 Feb 19. Eur Heart J. 2015. PMID: 24553721 Free PMC article.
Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype.
Hanssen NM, Wouters K, Huijberts MS, Gijbels MJ, Sluimer JC, Scheijen JL, Heeneman S, Biessen EA, Daemen MJ, Brownlee M, de Kleijn DP, Stehouwer CD, Pasterkamp G, Schalkwijk CG. Hanssen NM, et al. Among authors: sluimer jc. Eur Heart J. 2014 May;35(17):1137-46. doi: 10.1093/eurheartj/eht402. Epub 2013 Oct 14. Eur Heart J. 2014. PMID: 24126878
Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice.
Theelen TL, Lappalainen JP, Sluimer JC, Gurzeler E, Cleutjens JP, Gijbels MJ, Biessen EA, Daemen MJ, Alitalo K, Ylä-Herttuala S. Theelen TL, et al. Among authors: sluimer jc. Atherosclerosis. 2015 Aug;241(2):297-304. doi: 10.1016/j.atherosclerosis.2015.05.018. Epub 2015 Jun 3. Atherosclerosis. 2015. PMID: 26062989 Free PMC article.
Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia.
Marsch E, Demandt JA, Theelen TL, Tullemans BM, Wouters K, Boon MR, van Dijk TH, Gijbels MJ, Dubois LJ, Meex SJ, Mazzone M, Hung G, Fisher EA, Biessen EA, Daemen MJ, Rensen PC, Carmeliet P, Groen AK, Sluimer JC. Marsch E, et al. Among authors: sluimer jc. Eur Heart J. 2016 Oct 14;37(39):2993-2997. doi: 10.1093/eurheartj/ehw156. Epub 2016 Apr 28. Eur Heart J. 2016. PMID: 27125949 Free PMC article.
Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage.
Sluimer JC, Kolodgie FD, Bijnens AP, Maxfield K, Pacheco E, Kutys B, Duimel H, Frederik PM, van Hinsbergh VW, Virmani R, Daemen MJ. Sluimer JC, et al. J Am Coll Cardiol. 2009 Apr 28;53(17):1517-27. doi: 10.1016/j.jacc.2008.12.056. J Am Coll Cardiol. 2009. PMID: 19389562 Free PMC article.
91 results