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Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.
Lien F, Berthier A, Bouchaert E, Gheeraert C, Alexandre J, Porez G, Prawitt J, Dehondt H, Ploton M, Colin S, Lucas A, Patrice A, Pattou F, Diemer H, Van Dorsselaer A, Rachez C, Kamilic J, Groen AK, Staels B, Lefebvre P. Lien F, et al. Among authors: pattou f. J Clin Invest. 2014 Mar;124(3):1037-51. doi: 10.1172/JCI68815. Epub 2014 Feb 17. J Clin Invest. 2014. PMID: 24531544 Free PMC article.
Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans.
Lefebvre B, Benomar Y, Guédin A, Langlois A, Hennuyer N, Dumont J, Bouchaert E, Dacquet C, Pénicaud L, Casteilla L, Pattou F, Ktorza A, Staels B, Lefebvre P. Lefebvre B, et al. Among authors: pattou f. J Clin Invest. 2010 May;120(5):1454-68. doi: 10.1172/JCI38606. Epub 2010 Apr 1. J Clin Invest. 2010. PMID: 20364085 Free PMC article.
The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells.
Briand O, Helleboid-Chapman A, Ploton M, Hennuyer N, Carpentier R, Pattou F, Vandewalle B, Moerman E, Gmyr V, Kerr-Conte J, Eeckhoute J, Staels B, Lefebvre P. Briand O, et al. Among authors: pattou f. Mol Endocrinol. 2012 Mar;26(3):399-413. doi: 10.1210/me.2011-1317. Epub 2012 Feb 2. Mol Endocrinol. 2012. PMID: 22301783 Free PMC article.
Cell-specific dysregulation of microRNA expression in obese white adipose tissue.
Oger F, Gheeraert C, Mogilenko D, Benomar Y, Molendi-Coste O, Bouchaert E, Caron S, Dombrowicz D, Pattou F, Duez H, Eeckhoute J, Staels B, Lefebvre P. Oger F, et al. Among authors: pattou f. J Clin Endocrinol Metab. 2014 Aug;99(8):2821-33. doi: 10.1210/jc.2013-4259. Epub 2014 Apr 23. J Clin Endocrinol Metab. 2014. PMID: 24758184
MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids.
Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W. Fu X, et al. Among authors: pattou f. J Clin Invest. 2015 Jun;125(6):2497-509. doi: 10.1172/JCI75438. Epub 2015 May 11. J Clin Invest. 2015. PMID: 25961460 Free PMC article. Clinical Trial.
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.
Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, Perino A, Brighton CA, Sebti Y, Kluza J, Briand O, Dehondt H, Vallez E, Dorchies E, Baud G, Spinelli V, Hennuyer N, Caron S, Bantubungi K, Caiazzo R, Reimann F, Marchetti P, Lefebvre P, Bäckhed F, Gribble FM, Schoonjans K, Pattou F, Tailleux A, Staels B, Lestavel S. Trabelsi MS, et al. Among authors: pattou f. Nat Commun. 2015 Jul 2;6:7629. doi: 10.1038/ncomms8629. Nat Commun. 2015. PMID: 26134028 Free PMC article.
515 results