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Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.
Lien F, Berthier A, Bouchaert E, Gheeraert C, Alexandre J, Porez G, Prawitt J, Dehondt H, Ploton M, Colin S, Lucas A, Patrice A, Pattou F, Diemer H, Van Dorsselaer A, Rachez C, Kamilic J, Groen AK, Staels B, Lefebvre P. Lien F, et al. Among authors: bouchaert e. J Clin Invest. 2014 Mar;124(3):1037-51. doi: 10.1172/JCI68815. Epub 2014 Feb 17. J Clin Invest. 2014. PMID: 24531544 Free PMC article.
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity.
Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, Dumont J, Bouchaert E, van Dijk TH, Lucas A, Dorchies E, Daoudi M, Lestavel S, Gonzalez FJ, Oresic M, Cariou B, Kuipers F, Caron S, Staels B. Prawitt J, et al. Among authors: bouchaert e. Diabetes. 2011 Jul;60(7):1861-71. doi: 10.2337/db11-0030. Epub 2011 May 18. Diabetes. 2011. PMID: 21593203 Free PMC article.
Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans.
Lefebvre B, Benomar Y, Guédin A, Langlois A, Hennuyer N, Dumont J, Bouchaert E, Dacquet C, Pénicaud L, Casteilla L, Pattou F, Ktorza A, Staels B, Lefebvre P. Lefebvre B, et al. Among authors: bouchaert e. J Clin Invest. 2010 May;120(5):1454-68. doi: 10.1172/JCI38606. Epub 2010 Apr 1. J Clin Invest. 2010. PMID: 20364085 Free PMC article.
The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways.
Abdelkarim M, Caron S, Duhem C, Prawitt J, Dumont J, Lucas A, Bouchaert E, Briand O, Brozek J, Kuipers F, Fievet C, Cariou B, Staels B. Abdelkarim M, et al. Among authors: bouchaert e. J Biol Chem. 2010 Nov 19;285(47):36759-67. doi: 10.1074/jbc.M110.166231. Epub 2010 Sep 17. J Biol Chem. 2010. PMID: 20851881 Free PMC article.
Cell-specific dysregulation of microRNA expression in obese white adipose tissue.
Oger F, Gheeraert C, Mogilenko D, Benomar Y, Molendi-Coste O, Bouchaert E, Caron S, Dombrowicz D, Pattou F, Duez H, Eeckhoute J, Staels B, Lefebvre P. Oger F, et al. Among authors: bouchaert e. J Clin Endocrinol Metab. 2014 Aug;99(8):2821-33. doi: 10.1210/jc.2013-4259. Epub 2014 Apr 23. J Clin Endocrinol Metab. 2014. PMID: 24758184
FXR-deficiency confers increased susceptibility to torpor.
Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B. Cariou B, et al. Among authors: bouchaert e. FEBS Lett. 2007 Nov 13;581(27):5191-8. doi: 10.1016/j.febslet.2007.09.064. Epub 2007 Oct 12. FEBS Lett. 2007. PMID: 17950284 Free article.
Hepatic PPARα is critical in the metabolic adaptation to sepsis.
Paumelle R, Haas JT, Hennuyer N, Baugé E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B. Paumelle R, et al. Among authors: bouchaert e. J Hepatol. 2019 May;70(5):963-973. doi: 10.1016/j.jhep.2018.12.037. Epub 2019 Jan 21. J Hepatol. 2019. PMID: 30677458 Free PMC article.
Transient impairment of the adaptive response to fasting in FXR-deficient mice.
Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk T, Grefhorst A, Bouchaert E, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B. Cariou B, et al. Among authors: bouchaert e. FEBS Lett. 2005 Aug 1;579(19):4076-80. doi: 10.1016/j.febslet.2005.06.033. FEBS Lett. 2005. PMID: 16023103 Free article.
37 results