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Eμ/miR-125b transgenic mice develop lethal B-cell malignancies.
Enomoto Y, Kitaura J, Hatakeyama K, Watanuki J, Akasaka T, Kato N, Shimanuki M, Nishimura K, Takahashi M, Taniwaki M, Haferlach C, Siebert R, Dyer MJ, Asou N, Aburatani H, Nakakuma H, Kitamura T, Sonoki T. Enomoto Y, et al. Among authors: nishimura k. Leukemia. 2011 Dec;25(12):1849-56. doi: 10.1038/leu.2011.166. Epub 2011 Jul 8. Leukemia. 2011. PMID: 21738213
APC(CDH1) targets MgcRacGAP for destruction in the late M phase.
Nishimura K, Oki T, Kitaura J, Kuninaka S, Saya H, Sakaue-Sawano A, Miyawaki A, Kitamura T. Nishimura K, et al. PLoS One. 2013 May 16;8(5):e63001. doi: 10.1371/journal.pone.0063001. Print 2013. PLoS One. 2013. PMID: 23696789 Free PMC article.
Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.
Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T. Inoue D, et al. Among authors: nishimura k. J Clin Invest. 2013 Nov;123(11):4627-40. doi: 10.1172/JCI70739. J Clin Invest. 2013. PMID: 24216483 Free PMC article.
Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis.
Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T. Uchida T, et al. Among authors: nishimura k. Exp Hematol. 2014 May;42(5):369-379.e3. doi: 10.1016/j.exphem.2014.01.009. Epub 2014 Jan 31. Exp Hematol. 2014. PMID: 24486648 Free article. Clinical Trial.
A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm.
Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T. Togami K, et al. Among authors: nishimura k. Exp Hematol. 2015 Apr;43(4):300-8.e1. doi: 10.1016/j.exphem.2014.11.011. Epub 2014 Dec 20. Exp Hematol. 2015. PMID: 25534203 Free article.
4,128 results