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Page 1
A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.
Gajewiak J, Azam L, Imperial J, Walewska A, Green BR, Bandyopadhyay PK, Raghuraman S, Ueberheide B, Bern M, Zhou HM, Minassian NA, Hagan RH, Flinspach M, Liu Y, Bulaj G, Wickenden AD, Olivera BM, Yoshikami D, Zhang MM. Gajewiak J, et al. Among authors: flinspach m. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2758-63. doi: 10.1073/pnas.1324189111. Epub 2014 Feb 4. Proc Natl Acad Sci U S A. 2014. PMID: 24497506 Free PMC article.
Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a).
Minassian NA, Gibbs A, Shih AY, Liu Y, Neff RA, Sutton SW, Mirzadegan T, Connor J, Fellows R, Husovsky M, Nelson S, Hunter MJ, Flinspach M, Wickenden AD. Minassian NA, et al. Among authors: flinspach m. J Biol Chem. 2013 Aug 2;288(31):22707-20. doi: 10.1074/jbc.M113.461392. Epub 2013 Jun 12. J Biol Chem. 2013. PMID: 23760503 Free PMC article.
Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.
Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD. Flinspach M, et al. Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662. Sci Rep. 2017. PMID: 28045073 Free PMC article.
Double barrel shotgun scanning of the caveolin-1 scaffolding domain.
Levin AM, Murase K, Jackson PJ, Flinspach ML, Poulos TL, Weiss GA. Levin AM, et al. Among authors: flinspach ml. ACS Chem Biol. 2007 Jul 20;2(7):493-500. doi: 10.1021/cb700055t. Epub 2007 Jun 29. ACS Chem Biol. 2007. PMID: 17602618 Free PMC article.
Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.
Flinspach M, Li H, Jamal J, Yang W, Huang H, Silverman RB, Poulos TL. Flinspach M, et al. Biochemistry. 2004 May 11;43(18):5181-7. doi: 10.1021/bi0361867. Biochemistry. 2004. PMID: 15122883
The D-nitroarginine-containing dipeptide inhibitors are not distinguished by the amino acid difference between nNOS and eNOS (Asp 597 and Asn 368, respectively) which is key in controlling isoform selection for nNOS over eNOS observed for the L-nitroarginine-containing dipeptide …
The D-nitroarginine-containing dipeptide inhibitors are not distinguished by the amino acid difference between nNOS and eNOS (Asp 597 and As …
14 results