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Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.
Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M. Morihara T, et al. Among authors: suzuki t. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2638-43. doi: 10.1073/pnas.1307345111. Epub 2014 Feb 4. Proc Natl Acad Sci U S A. 2014. PMID: 24497505 Free PMC article.
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T. Saito Y, et al. Among authors: suzuki t. J Biol Chem. 2008 Dec 19;283(51):35763-71. doi: 10.1074/jbc.M801353200. Epub 2008 Oct 9. J Biol Chem. 2008. PMID: 18845544 Free PMC article.
The amyloidogenic, but not amyloidolytic, metabolism of APP was selectively increased in the brain of mutant mice lacking X11L (Sano, Y., Syuzo-Takabatake, A., Nakaya, T., Saito, Y., Tomita, S., Itohara, S., and Suzuki, T. (2006) J. ...
The amyloidogenic, but not amyloidolytic, metabolism of APP was selectively increased in the brain of mutant mice lacking X11L (Sano, Y., Sy …
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T. Hata S, et al. Among authors: suzuki t. J Biol Chem. 2009 Dec 25;284(52):36024-36033. doi: 10.1074/jbc.M109.057497. Epub 2009 Oct 28. J Biol Chem. 2009. PMID: 19864413 Free PMC article.
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