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Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy.
Benaim G, Casanova P, Hernandez-Rodriguez V, Mujica-Gonzalez S, Parra-Gimenez N, Plaza-Rojas L, Concepcion JL, Liu YL, Oldfield E, Paniz-Mondolfi A, Suarez AI. Benaim G, et al. Among authors: liu yl. Antimicrob Agents Chemother. 2014;58(4):2295-303. doi: 10.1128/AAC.01240-13. Epub 2014 Feb 3. Antimicrob Agents Chemother. 2014. PMID: 24492373 Free PMC article.
Squalene synthase as a target for Chagas disease therapeutics.
Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, de Carvalho TM, de Souza W, Urbina JA, Wang AH, Docampo R, Li K, Liu YL, Oldfield E, Guo RT. Shang N, et al. Among authors: liu yl. PLoS Pathog. 2014 May 1;10(5):e1004114. doi: 10.1371/journal.ppat.1004114. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24789335 Free PMC article.
Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.
Zhang Y, Zhu W, Liu YL, Wang H, Wang K, Li K, No JH, Ayong L, Gulati A, Pang R, Freitas-Junior L, Morita CT, Old-Field E. Zhang Y, et al. Among authors: liu yl. ACS Med Chem Lett. 2013 Apr 11;4(4):423-427. doi: 10.1021/ml4000436. ACS Med Chem Lett. 2013. PMID: 23610597 Free PMC article.
Bioorganometallic mechanism of action, and inhibition, of IspH.
Wang W, Wang K, Liu YL, No JH, Li J, Nilges MJ, Oldfield E. Wang W, et al. Among authors: liu yl. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4522-7. doi: 10.1073/pnas.0911087107. Epub 2010 Feb 19. Proc Natl Acad Sci U S A. 2010. PMID: 20173096 Free PMC article.
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.
No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E. No JH, et al. Among authors: liu yl. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4058-63. doi: 10.1073/pnas.1118215109. Epub 2012 Mar 5. Proc Natl Acad Sci U S A. 2012. PMID: 22392982 Free PMC article.
3,084 results