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Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy.
Benaim G, Casanova P, Hernandez-Rodriguez V, Mujica-Gonzalez S, Parra-Gimenez N, Plaza-Rojas L, Concepcion JL, Liu YL, Oldfield E, Paniz-Mondolfi A, Suarez AI. Benaim G, et al. Antimicrob Agents Chemother. 2014;58(4):2295-303. doi: 10.1128/AAC.01240-13. Epub 2014 Feb 3. Antimicrob Agents Chemother. 2014. PMID: 24492373 Free PMC article.
Amiodarone destabilizes intracellular Ca2+ homeostasis and biosynthesis of sterols in Leishmania mexicana.
Serrano-Martín X, García-Marchan Y, Fernandez A, Rodriguez N, Rojas H, Visbal G, Benaim G. Serrano-Martín X, et al. Among authors: benaim g. Antimicrob Agents Chemother. 2009 Apr;53(4):1403-10. doi: 10.1128/AAC.01215-08. Epub 2009 Jan 21. Antimicrob Agents Chemother. 2009. PMID: 19164149 Free PMC article.
We have recently shown that amiodarone, frequently used as an antiarrhythmic, possesses activity against Trypanosoma cruzi through the disruption of mitochondrial Ca(2+) homeostasis and the inhibition of parasite ergosterol biosynthesis, specifically at the level of oxidosqualene …
We have recently shown that amiodarone, frequently used as an antiarrhythmic, possesses activity against Trypanosoma cruzi through the disru …
Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis.
Serrano-Martín X, Payares G, De Lucca M, Martinez JC, Mendoza-León A, Benaim G. Serrano-Martín X, et al. Among authors: benaim g. Antimicrob Agents Chemother. 2009 Dec;53(12):5108-13. doi: 10.1128/AAC.00505-09. Epub 2009 Oct 5. Antimicrob Agents Chemother. 2009. PMID: 19805563 Free PMC article.
Serrano-Martin, Y. Garcia-Marchan, A. Fernandez, N. Rodriguez, H. Rojas, G. Visbal, and G. Benaim, Antimicrob. Agents Chemother. 53:1403-1410, 2009). ...
Serrano-Martin, Y. Garcia-Marchan, A. Fernandez, N. Rodriguez, H. Rojas, G. Visbal, and G. Benaim, Antimicrob. Agents C …
The marine sponge toxin agelasine B increases the intracellular Ca(2+) concentration and induces apoptosis in human breast cancer cells (MCF-7).
Pimentel AA, Felibertt P, Sojo F, Colman L, Mayora A, Silva ML, Rojas H, Dipolo R, Suarez AI, Compagnone RS, Arvelo F, Galindo-Castro I, De Sanctis JB, Chirino P, Benaim G. Pimentel AA, et al. Among authors: benaim g. Cancer Chemother Pharmacol. 2012 Jan;69(1):71-83. doi: 10.1007/s00280-011-1677-x. Epub 2011 May 21. Cancer Chemother Pharmacol. 2012. PMID: 21603866
97 results