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Aging of blood can be tracked by DNA methylation changes at just three CpG sites.
Weidner CI, Lin Q, Koch CM, Eisele L, Beier F, Ziegler P, Bauerschlag DO, Jöckel KH, Erbel R, Mühleisen TW, Zenke M, Brümmendorf TH, Wagner W. Weidner CI, et al. Among authors: brummendorf th. Genome Biol. 2014 Feb 3;15(2):R24. doi: 10.1186/gb-2014-15-2-r24. Genome Biol. 2014. PMID: 24490752 Free PMC article.
Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia.
Jost E, Lin Q, Weidner CI, Wilop S, Hoffmann M, Walenda T, Schemionek M, Herrmann O, Zenke M, Brümmendorf TH, Koschmieder S, Wagner W. Jost E, et al. Among authors: brummendorf th. Leukemia. 2014 Jun;28(6):1227-34. doi: 10.1038/leu.2013.362. Epub 2013 Nov 27. Leukemia. 2014. PMID: 24280869 Free PMC article.
Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites.
Hänzelmann S, Beier F, Gusmao EG, Koch CM, Hummel S, Charapitsa I, Joussen S, Benes V, Brümmendorf TH, Reid G, Costa IG, Wagner W. Hänzelmann S, et al. Among authors: brummendorf th. Clin Epigenetics. 2015 Mar 4;7(1):19. doi: 10.1186/s13148-015-0057-5. eCollection 2015. Clin Epigenetics. 2015. PMID: 25763115 Free PMC article.
Telomere shortening in enterocytes of patients with uncontrolled acute intestinal graft-versus-host disease.
Hummel S, Ventura Ferreira MS, Heudobler D, Huber E, Fahrenkamp D, Gremse F, Schmid K, Müller-Newen G, Ziegler P, Jost E, Blasco MA, Brümmendorf TH, Holler E, Beier F. Hummel S, et al. Among authors: brummendorf th. Blood. 2015 Nov 26;126(22):2518-21. doi: 10.1182/blood-2015-03-633289. Epub 2015 Oct 20. Blood. 2015. PMID: 26486788 Free article.
DNA-methylation in C1R is a prognostic biomarker for acute myeloid leukemia.
Božić T, Lin Q, Frobel J, Wilop S, Hoffmann M, Müller-Tidow C, Brümmendorf TH, Jost E, Wagner W. Božić T, et al. Among authors: brummendorf th. Clin Epigenetics. 2015 Nov 4;7:116. doi: 10.1186/s13148-015-0153-6. eCollection 2015. Clin Epigenetics. 2015. PMID: 26539253 Free PMC article.
DNA methylation in PRDM8 is indicative for dyskeratosis congenita.
Weidner CI, Lin Q, Birkhofer C, Gerstenmaier U, Kaifie A, Kirschner M, Bruns H, Balabanov S, Trummer A, Stockklausner C, Höchsmann B, Schrezenmeier H, Wlodarski M, Panse J, Brümmendorf TH, Beier F, Wagner W. Weidner CI, et al. Among authors: brummendorf th. Oncotarget. 2016 Mar 8;7(10):10765-72. doi: 10.18632/oncotarget.7458. Oncotarget. 2016. PMID: 26909595 Free PMC article.
351 results