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The C-terminal domain of the long form of cellular FLICE-inhibitory protein (c-FLIPL) inhibits the interaction of the caspase 8 prodomain with the receptor-interacting protein 1 (RIP1) death domain and regulates caspase 8-dependent nuclear factor κB (NF-κB) activation.
Matsuda I, Matsuo K, Matsushita Y, Haruna Y, Niwa M, Kataoka T. Matsuda I, et al. Among authors: kataoka t. J Biol Chem. 2014 Feb 14;289(7):3876-87. doi: 10.1074/jbc.M113.506485. Epub 2014 Jan 6. J Biol Chem. 2014. PMID: 24398693 Free PMC article.
The caspase-8 modulator c-FLIP.
Kataoka T. Kataoka T. Crit Rev Immunol. 2005;25(1):31-58. doi: 10.1615/critrevimmunol.v25.i1.30. Crit Rev Immunol. 2005. PMID: 15833082 Review.
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