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Safety and efficacy of chimeric yellow Fever-dengue virus tetravalent vaccine formulations in nonhuman primates.
Guirakhoo F, Pugachev K, Zhang Z, Myers G, Levenbook I, Draper K, Lang J, Ocran S, Mitchell F, Parsons M, Brown N, Brandler S, Fournier C, Barrere B, Rizvi F, Travassos A, Nichols R, Trent D, Monath T. Guirakhoo F, et al. Among authors: pugachev k. J Virol. 2004 May;78(9):4761-75. doi: 10.1128/jvi.78.9.4761-4775.2004. J Virol. 2004. PMID: 15078958 Free PMC article.
ChimeriVax-DEN1-4 vaccine viruses were prepared by electroporation of Vero cells with RNA transcripts prepared from viral cDNA (F. Guirakhoo, J. Arroyo, K. V. Pugachev, C. Miller, Z.-X. Zhang, R. Weltzin, K. Georgakopoulos, J. ...Guirakhoo, K. Pugac …
ChimeriVax-DEN1-4 vaccine viruses were prepared by electroporation of Vero cells with RNA transcripts prepared from viral cDNA (F. Guirakhoo …
Construction and biological characterization of artificial recombinants between a wild type flavivirus (Kunjin) and a live chimeric flavivirus vaccine (ChimeriVax-JE).
Pugachev KV, Schwaiger J, Brown N, Zhang ZX, Catalan J, Mitchell FS, Ocran SW, Rumyantsev AA, Khromykh AA, Monath TP, Guirakhoo F. Pugachev KV, et al. Vaccine. 2007 Sep 17;25(37-38):6661-71. doi: 10.1016/j.vaccine.2007.07.016. Epub 2007 Jul 27. Vaccine. 2007. PMID: 17693000
Although the theoretical concern of genetic recombination has been raised related to the use of live attenuated flavivirus vaccines [Seligman, Gould, Lancet 2004;363:2073-5], it has little foundation [e.g., Monath TP, Kanesa-Thasan N, Guirakhoo F, Pugachev K, Almond …
Although the theoretical concern of genetic recombination has been raised related to the use of live attenuated flavivirus vaccines [Seligma …
Viremia and immunogenicity in nonhuman primates of a tetravalent yellow fever-dengue chimeric vaccine: genetic reconstructions, dose adjustment, and antibody responses against wild-type dengue virus isolates.
Guirakhoo F, Pugachev K, Arroyo J, Miller C, Zhang ZX, Weltzin R, Georgakopoulos K, Catalan J, Ocran S, Draper K, Monath TP. Guirakhoo F, et al. Among authors: pugachev k. Virology. 2002 Jun 20;298(1):146-59. doi: 10.1006/viro.2002.1462. Virology. 2002. PMID: 12093182 Free article.
A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys.
Guirakhoo F, Zhang Z, Myers G, Johnson BW, Pugachev K, Nichols R, Brown N, Levenbook I, Draper K, Cyrek S, Lang J, Fournier C, Barrere B, Delagrave S, Monath TP. Guirakhoo F, et al. Among authors: pugachev k. J Virol. 2004 Sep;78(18):9998-10008. doi: 10.1128/JVI.78.18.9998-10008.2004. J Virol. 2004. PMID: 15331733 Free PMC article.
During subsequent cell culture passaging of this clone for vaccine production, a single amino acid substitution (K to R) occurred in the envelope (E) protein at residue 204 (E204) (F. Guirakhoo, K. Pugachev, Z. Zhang, G. Myers, I. Levenbook, K. Draper, …
During subsequent cell culture passaging of this clone for vaccine production, a single amino acid substitution (K to R) occurred in …
Traditional and novel approaches to flavivirus vaccines.
Pugachev KV, Guirakhoo F, Trent DW, Monath TP. Pugachev KV, et al. Int J Parasitol. 2003 May;33(5-6):567-82. doi: 10.1016/s0020-7519(03)00063-8. Int J Parasitol. 2003. PMID: 12782056 Review.
87 results