Varela MA - Search Results

1

Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective.

Fernandes SA, Douglas AG, Varela MA, Wood MJ, Aoki Y. Fernandes SA, et al. Among authors: varela ma. J Nucleic Acids. 2013;2013:208245. doi: 10.1155/2013/208245. Epub 2013 Nov 17. J Nucleic Acids. 2013. PMID: 24349764 Free PMC article. Review.

2

Natural Antisense Makes Sense for Gene-specific Activation in Brain.

Varela MA, Roberts TC, Andaloussi SE, Wood MJ. Varela MA, et al. Mol Ther Nucleic Acids. 2012 May 15;1(5):e24. doi: 10.1038/mtna.2012.17. Mol Ther Nucleic Acids. 2012. PMID: 23344004 Free PMC article. No abstract available.

3

Epigenetics and ncRNAs in brain function and disease: mechanisms and prospects for therapy.

Varela MA, Roberts TC, Wood MJ. Varela MA, et al. Neurotherapeutics. 2013 Oct;10(4):621-31. doi: 10.1007/s13311-013-0212-7. Neurotherapeutics. 2013. PMID: 24068583 Free PMC article. Review.

4

Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7.

Tan JY, Vance KW, Varela MA, Sirey T, Watson LM, Curtis HJ, Marinello M, Alves S, Steinkraus B, Cooper S, Nesterova T, Brockdorff N, Fulga T, Brice A, Sittler A, Oliver PL, Wood MJ, Ponting CP, Marques AC. Tan JY, et al. Among authors: varela ma. Nat Struct Mol Biol. 2014 Nov;21(11):955-961. doi: 10.1038/nsmb.2902. Epub 2014 Oct 12. Nat Struct Mol Biol. 2014. PMID: 25306109 Free PMC article.

5

Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides.

Hammond SM, McClorey G, Nordin JZ, Godfrey C, Stenler S, Lennox KA, Smith CI, Jacobi AM, Varela MA, Lee Y, Behlke MA, Wood MJ, Andaloussi SE. Hammond SM, et al. Among authors: varela ma. Mol Ther Nucleic Acids. 2014 Nov 25;3(11):e212. doi: 10.1038/mtna.2014.63. Mol Ther Nucleic Acids. 2014. PMID: 25423116 Free PMC article.

6

Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice.

Betts CA, Saleh AF, Carr CA, Hammond SM, Coenen-Stass AM, Godfrey C, McClorey G, Varela MA, Roberts TC, Clarke K, Gait MJ, Wood MJ. Betts CA, et al. Among authors: varela ma. Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986. Sci Rep. 2015. PMID: 25758104 Free PMC article.

7

Transfer of genetic therapy across human populations: molecular targets for increasing patient coverage in repeat expansion diseases.

Varela MA, Curtis HJ, Douglas AG, Hammond SM, O'Loughlin AJ, Sobrido MJ, Scholefield J, Wood MJ. Varela MA, et al. Eur J Hum Genet. 2016 Feb;24(2):271-6. doi: 10.1038/ejhg.2015.94. Epub 2015 May 20. Eur J Hum Genet. 2016. PMID: 25990798 Free PMC article.

8

C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia.

Aoki Y, Manzano R, Lee Y, Dafinca R, Aoki M, Douglas AGL, Varela MA, Sathyaprakash C, Scaber J, Barbagallo P, Vader P, Mäger I, Ezzat K, Turner MR, Ito N, Gasco S, Ohbayashi N, El Andaloussi S, Takeda S, Fukuda M, Talbot K, Wood MJA. Aoki Y, et al. Among authors: varela ma. Brain. 2017 Apr 1;140(4):887-897. doi: 10.1093/brain/awx024. Brain. 2017. PMID: 28334866

9

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles.

O'Loughlin AJ, Mäger I, de Jong OG, Varela MA, Schiffelers RM, El Andaloussi S, Wood MJA, Vader P. O'Loughlin AJ, et al. Among authors: varela ma. Mol Ther. 2017 Jul 5;25(7):1580-1587. doi: 10.1016/j.ymthe.2017.03.021. Epub 2017 Apr 6. Mol Ther. 2017. PMID: 28392161 Free PMC article.

10

Knockdown and replacement therapy mediated by artificial mirtrons in spinocerebellar ataxia 7.

Curtis HJ, Seow Y, Wood MJA, Varela MA. Curtis HJ, et al. Among authors: varela ma. Nucleic Acids Res. 2017 Jul 27;45(13):7870-7885. doi: 10.1093/nar/gkx483. Nucleic Acids Res. 2017. PMID: 28575281 Free PMC article.

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