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The Wobbler mouse model of amyotrophic lateral sclerosis (ALS) displays hippocampal hyperexcitability, and reduced number of interneurons, but no presynaptic vesicle release impairments.
PLoS One. 2013 Dec 11;8(12):e82767. doi: 10.1371/journal.pone.0082767. eCollection 2013.
PLoS One. 2013.
PMID: 24349357
Free PMC article.
Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam.
Andreasen SR, Lundbye CJ, Christensen TB, Thielsen KD, Schmitt-John T, Holm MM.
Andreasen SR, et al. Among authors: thielsen kd.
Neurosci Lett. 2017 Sep 29;658:85-90. doi: 10.1016/j.neulet.2017.08.033. Epub 2017 Aug 18.
Neurosci Lett. 2017.
PMID: 28823891
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