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Quantitative assays for esterified oxylipins generated by immune cells.
Morgan AH, Hammond VJ, Morgan L, Thomas CP, Tallman KA, Garcia-Diaz YR, McGuigan C, Serpi M, Porter NA, Murphy RC, O'Donnell VB. Morgan AH, et al. Among authors: hammond vj. Nat Protoc. 2010 Dec;5(12):1919-31. doi: 10.1038/nprot.2010.162. Epub 2010 Nov 10. Nat Protoc. 2010. PMID: 21127486 Free PMC article.
Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection.
Clark SR, Guy CJ, Scurr MJ, Taylor PR, Kift-Morgan AP, Hammond VJ, Thomas CP, Coles B, Roberts GW, Eberl M, Jones SA, Topley N, Kotecha S, O'Donnell VB. Clark SR, et al. Among authors: hammond vj. Blood. 2011 Feb 10;117(6):2033-43. doi: 10.1182/blood-2010-04-278887. Epub 2010 Dec 21. Blood. 2011. PMID: 21177434 Free PMC article.
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M. Friedmann Angeli JP, et al. Among authors: hammond vj. Nat Cell Biol. 2014 Dec;16(12):1180-91. doi: 10.1038/ncb3064. Epub 2014 Nov 17. Nat Cell Biol. 2014. PMID: 25402683 Free PMC article.
A novel role for 12/15-lipoxygenase in regulating autophagy.
Morgan AH, Hammond VJ, Sakoh-Nakatogawa M, Ohsumi Y, Thomas CP, Blanchet F, Piguet V, Kiselyov K, O'Donnell VB. Morgan AH, et al. Among authors: hammond vj. Redox Biol. 2015;4:40-7. doi: 10.1016/j.redox.2014.11.005. Epub 2014 Dec 3. Redox Biol. 2015. PMID: 25498966 Free PMC article.
Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G. Uderhardt S, et al. Among authors: hammond vj. J Exp Med. 2017 Jul 3;214(7):2121-2138. doi: 10.1084/jem.20161070. Epub 2017 May 31. J Exp Med. 2017. PMID: 28566277 Free PMC article.
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.
Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB. Hammond VJ, et al. J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11. J Biol Chem. 2012. PMID: 23060450 Free PMC article. Clinical Trial.
17 results