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Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models.
Everett MJ, Davies DT, Leiris S, Sprynski N, Llanos A, Castandet JM, Lozano C, LaRock CN, LaRock DL, Corsica G, Docquier JD, Pallin TD, Cridland A, Blench T, Zalacain M, Lemonnier M. Everett MJ, et al. Among authors: larock cn. ACS Infect Dis. 2023 Feb 10;9(2):270-282. doi: 10.1021/acsinfecdis.2c00418. Epub 2023 Jan 20. ACS Infect Dis. 2023. PMID: 36669138 Free PMC article.
IL-1β is an innate immune sensor of microbial proteolysis.
LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V. LaRock CN, et al. Among authors: larock dl. Sci Immunol. 2016 Aug;1(2):eaah3539. doi: 10.1126/sciimmunol.aah3539. Epub 2016 Aug 19. Sci Immunol. 2016. PMID: 28331908 Free PMC article.
Group A streptococcal M protein activates the NLRP3 inflammasome.
Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. Valderrama JA, et al. Among authors: larock cn. Nat Microbiol. 2017 Oct;2(10):1425-1434. doi: 10.1038/s41564-017-0005-6. Epub 2017 Aug 7. Nat Microbiol. 2017. PMID: 28784982 Free PMC article.
Modeling neuro-immune interactions during Zika virus infection.
Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, de A Zanotto PM, Beltrão-Braga PCB, Nizet V, Muotri AR. Mesci P, et al. Among authors: larock cn. Hum Mol Genet. 2018 Jan 1;27(1):41-52. doi: 10.1093/hmg/ddx382. Hum Mol Genet. 2018. PMID: 29048558 Free PMC article.
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells.
Dan JM, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales SL, Anderson EL, LaRock CN, Vijayanand P, Seumois G, Layfield D, Cutress RI, Ottensmeier CH, Lindestam Arlehamn CS, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Dan JM, et al. Among authors: larock cn. Sci Transl Med. 2019 Feb 6;11(478):eaau3776. doi: 10.1126/scitranslmed.aau3776. Sci Transl Med. 2019. PMID: 30728285 Free PMC article.
34 results