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The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies.
Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, Simen BB, St John EP, Chan-Hui PY, Swiderek K, Kleinstein SH, Alter G, Seaman MS, Chakraborty AK, Koller D, Wilson IA, Church GM, Burton DR, Poignard P. Sok D, et al. Among authors: mahan a. PLoS Pathog. 2013;9(11):e1003754. doi: 10.1371/journal.ppat.1003754. Epub 2013 Nov 21. PLoS Pathog. 2013. PMID: 24278016 Free PMC article. Clinical Trial.
Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination.
Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, Alter G. Mahan AE, et al. PLoS Pathog. 2016 Mar 16;12(3):e1005456. doi: 10.1371/journal.ppat.1005456. eCollection 2016 Mar. PLoS Pathog. 2016. PMID: 26982805 Free PMC article.
Microscale purification of antigen-specific antibodies.
Brown EP, Normandin E, Osei-Owusu NY, Mahan AE, Chan YN, Lai JI, Vaccari M, Rao M, Franchini G, Alter G, Ackerman ME. Brown EP, et al. J Immunol Methods. 2015 Oct;425:27-36. doi: 10.1016/j.jim.2015.06.005. Epub 2015 Jun 12. J Immunol Methods. 2015. PMID: 26078040 Free PMC article.
Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16.
Gunn B, Schneider J, Shansab M, Bastian AR, Fahrbach K, Smith A 4th, Mahan A, Karim M, Licht A, Zvonar I, Tedesco J, Anderson M, Chapel A, Suscovich T, Malaspina D, Streeck H, Walker BD, Kim A, Lauer G, Altfeld M, Pillai S, Szleifer I, Kelleher NL, Kiser PF, Hope TJ, Alter G. Gunn B, et al. Among authors: mahan a. Mucosal Immunol. 2016 Nov;9(6):1549-1558. doi: 10.1038/mi.2016.8. Epub 2016 Mar 9. Mucosal Immunol. 2016. PMID: 26960182 Free PMC article.
Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.
Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, Pau MG, Baden LR, Kim JH, Michael NL, Barouch DH, Lauffenburger DA, Alter G. Chung AW, et al. Among authors: mahan ae. Cell. 2015 Nov 5;163(4):988-98. doi: 10.1016/j.cell.2015.10.027. Cell. 2015. PMID: 26544943 Free PMC article.
A Functional Role for Antibodies in Tuberculosis.
Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, Tkachenko E, Draghi M, Freedberg KJ, Streeck H, Suscovich TJ, Lauffenburger DA, Restrepo BI, Day C, Fortune SM, Alter G. Lu LL, et al. Among authors: mahan ae. Cell. 2016 Oct 6;167(2):433-443.e14. doi: 10.1016/j.cell.2016.08.072. Epub 2016 Sep 22. Cell. 2016. PMID: 27667685 Free PMC article.
73 results